23 May 2018
Vol 10, Issue 442

About The Cover

Cover image expansion

ONLINE COVER Stimulating Glucose Control. This image depicts deep brain stimulation (DBS), a method used to deliver electrical stimuli to specific brain areas. Ter Horst et al. showed that DBS applied to the striatal area of the brain promoted dopamine release that in turn increased hepatic and peripheral insulin sensitivity in patients with type 2 diabetes. Conversely, pharmacological dopamine depletion reduced systemic insulin sensitivity in healthy subjects. The findings highlight an underappreciated link between brain dopamine and systemic glucose metabolism and suggest that modulation of brain dopamine could be a potential strategy for treating diabetes.