Research ArticleStroke

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

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Science Translational Medicine  16 May 2018:
Vol. 10, Issue 441, eaao6459
DOI: 10.1126/scitranslmed.aao6459

Stroke therapy goes local

The complement system is activated by ischemic stroke to promote tissue repair. However, long-lasting systemic activation leads to the development of neurological impairments. Alawieh et al. show that specific local complement inhibition reduced cell death and inflammation induced by stroke and promoted functional recovery in a mouse model. Targeted complement inhibition was obtained by linking a complement inhibitor to an antibody recognizing neoepitopes locally and transiently expressed in the ischemic area of the mouse brain. The authors also show that the targeted neoepitope was overexpressed in the ischemic region of brain tissue from stroke patients, suggesting that the same approach potentially might be effective in the clinical setting.

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