16 May 2018
Vol 10, Issue 441

About The Cover

Cover image expansion

ONLINE COVER Curbing Complement During Stroke Recovery. This image shows a microglial cell (yellow) attached to an ischemic neuron (gray) that has been tagged by complement proteins (blue). Although the complement system can be effective at promoting tissue repair after stroke, long-lasting activation in the region of ischemic injury leads to neurodegeneration. To contain complement activation after stroke, Alawieh et al. developed a transient, ischemia-specific complement inhibitor that limited neurodegeneration in a mouse model of cerebral ischemia. The inhibitor did not affect the regenerative process induced by complement. Analysis of postmortem brain tissue from patients with ischemia suggested that the same approach might be useful for treating patients after stroke. [CREDIT: EMMA C. VOUGHT/MUSC]