Research ArticleTissue Engineering
Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
- Maximilian Y. Emmert1,2,3,*,
- Boris A. Schmitt4,5,*,
- Sandra Loerakker6,7,*,
- Bart Sanders6,7,*,
- Hendrik Spriestersbach4,5,
- Emanuela S. Fioretta1,
- Leon Bruder4,5,
- Kerstin Brakmann4,5,
- Sarah E. Motta1,
- Valentina Lintas1,
- Petra E. Dijkman1,
- Laura Frese1,
- Felix Berger4,5,†,
- Frank P. T. Baaijens6,7,† and
- Simon P. Hoerstrup1,3,†,‡
- 1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
- 2University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
- 3Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
- 4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
- 5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
- 6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
- 7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
- ↵‡Corresponding author. Email: simon.hoerstrup{at}irem.uzh.ch
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Science Translational Medicine 09 May 2018:
Vol. 10, Issue 440, eaan4587
DOI: 10.1126/scitranslmed.aan4587
Vol. 10, Issue 440, eaan4587
DOI: 10.1126/scitranslmed.aan4587
Maximilian Y. Emmert
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Boris A. Schmitt
German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Sandra Loerakker
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Bart Sanders
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Hendrik Spriestersbach
German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Emanuela S. Fioretta
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Leon Bruder
German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Kerstin Brakmann
German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Sarah E. Motta
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Valentina Lintas
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Petra E. Dijkman
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Laura Frese
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Felix Berger
German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Frank P. T. Baaijens
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Simon P. Hoerstrup
Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
