Research ArticleTissue Engineering
Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
- View ORCID ProfileMaximilian Y. Emmert1,2,3,*,
- View ORCID ProfileBoris A. Schmitt4,5,*,
- View ORCID ProfileSandra Loerakker6,7,*,
- View ORCID ProfileBart Sanders6,7,*,
- View ORCID ProfileHendrik Spriestersbach4,5,
- View ORCID ProfileEmanuela S. Fioretta1,
- View ORCID ProfileLeon Bruder4,5,
- Kerstin Brakmann4,5,
- Sarah E. Motta1,
- View ORCID ProfileValentina Lintas1,
- Petra E. Dijkman1,
- View ORCID ProfileLaura Frese1,
- Felix Berger4,5,†,
- Frank P. T. Baaijens6,7,† and
- View ORCID ProfileSimon P. Hoerstrup1,3,†,‡
- 1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
- 2University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
- 3Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
- 4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
- 5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
- 6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
- 7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
- ↵‡Corresponding author. Email: simon.hoerstrup{at}irem.uzh.ch
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Science Translational Medicine 09 May 2018:
Vol. 10, Issue 440, eaan4587
DOI: 10.1126/scitranslmed.aan4587
Vol. 10, Issue 440, eaan4587
DOI: 10.1126/scitranslmed.aan4587
Maximilian Y. Emmert
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
2University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland.
3Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Boris A. Schmitt
4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Sandra Loerakker
6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Bart Sanders
6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Hendrik Spriestersbach
4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Emanuela S. Fioretta
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Leon Bruder
4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Kerstin Brakmann
4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Sarah E. Motta
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Valentina Lintas
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Petra E. Dijkman
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Laura Frese
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
Felix Berger
4German Heart Center Berlin and Charité—Universitätsmedizin Berlin, Department of Congenital Heart Disease, Berlin, Germany.
5DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Frank P. T. Baaijens
6Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands.
7Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands.
Simon P. Hoerstrup
1Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland.
3Wyss Translational Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
