Contents
09 May 2018
Vol 10, Issue 440
Vol 10, Issue 440
Focus
- The root problem of heart valve engineering
Acellular heart valve grafts optimized through computational modeling recellularize and function in sheep for up to 1 year (Emmert et al., this issue).
Research Articles
- Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model
Computational modeling–inspired heart valve designs guide tissue remodeling and ensure long-term functionality in tissue-engineered heart valves in sheep.
- Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs
Syngeneic iPSC–derived neurons survive and mature without immunosuppression after grafting into the spinal cord of adult pigs.
- Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress
High environmental humidity rescues atopic dermatitis-like signs in mice, and CLCA2 protects the epidermis from hyperosmotic stress.
- High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides
The malignant T cell clone frequency in cutaneous T cell lymphoma lesions is an independent prognostic indicator for early disease progression and death.
- PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production
RSV-induced prostaglandin D2 release contributes to disease severity by impairing IFN-λ production.
Editors' Choice
- Memorable cerebral inflammation
Exposure to peripheral inflammation induces microglia to alter subsequent course of stroke and Alzheimer’s pathologies.
- Sweet skin remedy
Up-regulation of glucose transport drives keratinocyte proliferation, whereas its inhibition offers therapeutic potential against psoriasis.
- Inflammatory signatures of smoking
Smoking is associated with distinct pro- and anti-inflammatory signatures in squamous cell carcinomas of the lung and the head and neck.
About The Cover
ONLINE COVER Spinal Cord Saviors. Depicted here is a mixed population of neurons after allogeneic transplant of induced pluripotent stem cell-derived neuronal precursor cells (iPSC-NPCs) into spinal cord lesions in minipigs. The colors correspond to the neuronal differentiation state, with the red-yellow color indicating immature neurons and the pink-blue color indicating mature neurons. Strnadel et al. demonstrated the long-term viability and safety of iPSC-NPC syngeneic and allogeneic transplants in a large animal model, paving the way for future clinical evaluation of iPSC-NPCs for treating spinal cord injury. [CREDIT: STRNADEL ET AL./SCIENCE TRANSLATIONAL MEDICINE]