09 May 2018
Vol 10, Issue 440

About The Cover

Cover image expansion

ONLINE COVER Spinal Cord Saviors. Depicted here is a mixed population of neurons after allogeneic transplant of induced pluripotent stem cell-derived neuronal precursor cells (iPSC-NPCs) into spinal cord lesions in minipigs. The colors correspond to the neuronal differentiation state, with the red-yellow color indicating immature neurons and the pink-blue color indicating mature neurons. Strnadel et al. demonstrated the long-term viability and safety of iPSC-NPC syngeneic and allogeneic transplants in a large animal model, paving the way for future clinical evaluation of iPSC-NPCs for treating spinal cord injury. [CREDIT: STRNADEL ET AL./SCIENCE TRANSLATIONAL MEDICINE]