Research ArticleCancer
Development of a stress response therapy targeting aggressive prostate cancer
- Hao G. Nguyen1,*,
- Crystal S. Conn1,*,†,
- Yae Kye1,
- Lingru Xue1,
- Craig M. Forester2,
- Janet E. Cowan1,
- Andrew C. Hsieh1,‡,
- John T. Cunningham1,§,
- Charles Truillet3,
- Feven Tameire4,
- Michael J. Evans3,
- Christopher P. Evans5,
- Joy C. Yang5,
- Byron Hann6,
- Constantinos Koumenis4,
- Peter Walter7,
- Peter R. Carroll1 and
- Davide Ruggero1,8,†
- 1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
- 2Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, UCSF, San Francisco, CA 94158, USA.
- 3Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
- 4Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
- 6Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.
- 7Department of Biochemistry and Biophysics, UCSF, Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
- 8Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA.
- ↵†Corresponding author. Email: crystal.conn{at}ucsf.edu (C.S.C.); davide.ruggero{at}ucsf.edu (D.R.)
↵* These authors contributed equally to this work.
↵‡ Present address: Fred Hutchinson Cancer Research Center and the Department of Medicine, University of Washington, Seattle, WA 98195, USA.
↵§ Present address: Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
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Science Translational Medicine 02 May 2018:
Vol. 10, Issue 439, eaar2036
DOI: 10.1126/scitranslmed.aar2036
Vol. 10, Issue 439, eaar2036
DOI: 10.1126/scitranslmed.aar2036
Hao G. Nguyen
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Crystal S. Conn
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Yae Kye
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Lingru Xue
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Craig M. Forester
Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, UCSF, San Francisco, CA 94158, USA.
Janet E. Cowan
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Andrew C. Hsieh
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
John T. Cunningham
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Charles Truillet
Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
Feven Tameire
Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael J. Evans
Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
Christopher P. Evans
Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Joy C. Yang
Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Byron Hann
Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.
Constantinos Koumenis
Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Peter Walter
Department of Biochemistry and Biophysics, UCSF, Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
Peter R. Carroll
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Davide Ruggero
School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA.
