Research ArticleCancer
Development of a stress response therapy targeting aggressive prostate cancer
- Hao G. Nguyen1,*,
- View ORCID ProfileCrystal S. Conn1,*,†,
- View ORCID ProfileYae Kye1,
- View ORCID ProfileLingru Xue1,
- View ORCID ProfileCraig M. Forester2,
- View ORCID ProfileJanet E. Cowan1,
- View ORCID ProfileAndrew C. Hsieh1,‡,
- View ORCID ProfileJohn T. Cunningham1,§,
- View ORCID ProfileCharles Truillet3,
- View ORCID ProfileFeven Tameire4,
- View ORCID ProfileMichael J. Evans3,
- View ORCID ProfileChristopher P. Evans5,
- Joy C. Yang5,
- View ORCID ProfileByron Hann6,
- View ORCID ProfileConstantinos Koumenis4,
- View ORCID ProfilePeter Walter7,
- Peter R. Carroll1 and
- View ORCID ProfileDavide Ruggero1,8,†
- 1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
- 2Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, UCSF, San Francisco, CA 94158, USA.
- 3Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
- 4Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
- 6Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.
- 7Department of Biochemistry and Biophysics, UCSF, Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
- 8Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA.
- ↵†Corresponding author. Email: crystal.conn{at}ucsf.edu (C.S.C.); davide.ruggero{at}ucsf.edu (D.R.)
↵* These authors contributed equally to this work.
↵‡ Present address: Fred Hutchinson Cancer Research Center and the Department of Medicine, University of Washington, Seattle, WA 98195, USA.
↵§ Present address: Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
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Science Translational Medicine 02 May 2018:
Vol. 10, Issue 439, eaar2036
DOI: 10.1126/scitranslmed.aar2036
Vol. 10, Issue 439, eaar2036
DOI: 10.1126/scitranslmed.aar2036
Hao G. Nguyen
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Crystal S. Conn
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Yae Kye
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Lingru Xue
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Craig M. Forester
2Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, UCSF, San Francisco, CA 94158, USA.
Janet E. Cowan
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Andrew C. Hsieh
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
John T. Cunningham
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Charles Truillet
3Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
Feven Tameire
4Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael J. Evans
3Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA 94158, USA.
Christopher P. Evans
5Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Joy C. Yang
5Department of Urology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Byron Hann
6Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA 94158, USA.
Constantinos Koumenis
4Department of Radiation Oncology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Peter Walter
7Department of Biochemistry and Biophysics, UCSF, Howard Hughes Medical Institute, San Francisco, CA 94158, USA.
Peter R. Carroll
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
Davide Ruggero
1School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA 94158, USA.
8Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA 94158, USA.
