02 May 2018
Vol 10, Issue 439
  • Focus

    • ER stress in prostate cancer: A therapeutically exploitable vulnerability?

      Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al., this issue).

  • Research Articles

    • Development of a stress response therapy targeting aggressive prostate cancer

      The PERK-eIF2α pathway is activated in aggressive prostate cancer and associated with patient outcome, providing a therapeutic target for the disease.

    • Microbial ecology perturbation in human IgA deficiency

      IgA influences bacterial fitness in the intestinal lumen and is only partially compensated for by IgM in selective IgA-deficient patients.

    • TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy

      SIV-infected rhesus macaques on antiretroviral therapy experienced a reduction in the SIV reservoir after treatment with TLR7 agonists.

    • Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates

      Low arginine vasopressin concentrations in cerebrospinal fluid may reflect low sociality in primates.

  • Editors' Choice

    • Gene transfer delivers (β-globin)

      Transplantation of genetically engineered hematopoietic stem cells eliminates or reduces transfusion dependence in β-thalassemia.

    • Alerting stem cells to regenerate

      Alarmin delivery accelerates tissue regeneration by transitioning quiescent stem cells to the metabolically active GAlert state.

About The Cover

Cover image expansion

ONLINE COVER Commensal Curation by IgA. Pictured here is one of billions of bacteria in the gut that can be recognized and bound by mucosal IgA. Mouse models of IgA deficiency exhibit profound microbial-dependent defects that are not observed in humans naturally deficient in IgA. To discern the role of IgA in human gut health, Fadlallah et al. examined the fecal microbiome from healthy people and IgA-deficient patients. Although IgM could partially compensate for the lack of IgA to prevent overt microbial imbalance, different bacteria were prominent in the two groups of people. Their findings show how IgA curates gut bacteria to shape the microbiome in humans. [CREDIT: FADLALLAH ET AL./SCIENCE TRANSLATIONAL MEDICINE]