Research ArticlePulmonary Arterial Hypertension

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation

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Science Translational Medicine  25 Apr 2018:
Vol. 10, Issue 438, eaao0303
DOI: 10.1126/scitranslmed.aao0303

Article Information

vol. 10 no. 438

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History: 
  • Received for publication June 8, 2017
  • Resubmitted November 18, 2017
  • Accepted for publication March 12, 2018
  • .

Author Information

  1. Ekaterina Legchenko1,
  2. Philippe Chouvarine1,
  3. Paul Borchert1,
  4. Angeles Fernandez-Gonzalez2,
  5. Erin Snay3,
  6. Martin Meier4,
  7. Lavinia Maegel5,6,7,
  8. S. Alex Mitsialis2,
  9. Eva A. Rog-Zielinska8,
  10. Stella Kourembanas2,
  11. Danny Jonigk5,6,7 and
  12. Georg Hansmann1,*
  1. 1Department of Pediatric Cardiology and Critical Care, Pulmonary Vascular Research Center, Hannover Medical School, Hannover, Germany.
  2. 2Division of Newborn Medicine, Department of Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  3. 3Division of Nuclear Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  4. 4Small Animal Imaging Center, Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
  5. 5Institute of Pathology, Hannover Medical School, Hannover, Germany.
  6. 6Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Hannover, Germany.
  7. 7The German Center for Lung Research (Deutsches Zentrum für Lungenforschung DZL), Giessen, Germany.
  8. 8Institute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center–University of Freiburg, and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  1. *Corresponding author. Email: georg.hansmann{at}gmail.com

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