Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

Michela Frascoli; Lacy Coniglio; Russell Witt; Cerine Jeanty; Shannon Fleck-Derderian; Dana E. Myers; Tzong-Hae Lee; Sheila Keating; Michael P. Busch; Philip J. Norris; Qizhi Tang; Giovanna Cruz; Lisa F. Barcellos; Nardhy Gomez-Lopez; Roberto Romero; Tippi C. MacKenzie

doi:10.1126/scitranslmed.aan2263

Research ArticleFETAL IMMUNITY

Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

View ORCID ProfileMichela Frascoli ¹,²,
View ORCID ProfileLacy Coniglio¹,²,
View ORCID ProfileRussell Witt¹,²,
Cerine Jeanty¹,²,
Shannon Fleck-Derderian³,
Dana E. Myers⁴,
Tzong-Hae Lee⁵,
View ORCID ProfileSheila Keating⁵,
Michael P. Busch⁵,
View ORCID ProfilePhilip J. Norris⁵,
View ORCID ProfileQizhi Tang²,
Giovanna Cruz⁶,
Lisa F. Barcellos⁶,
View ORCID ProfileNardhy Gomez-Lopez⁷,⁸,⁹,
View ORCID ProfileRoberto Romero⁷,¹⁰,¹¹,¹² and
View ORCID ProfileTippi C. MacKenzie ¹,²,¹³,*

¹Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
²Department of Surgery, University of California, San Francisco, CA 94143, USA.
³Department of Pediatrics, University of California, San Francisco, CA 94143, USA.
⁴Obstetrics and Gynecology, University of California, San Francisco, CA 94143, USA.
⁵Blood Systems Research Institute, San Francisco, CA 94118, USA.
⁶Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA.
⁷Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/National Institutes of Health (NIH)/U.S. Department of Health and Human Services (DHHS), Bethesda, MD 20892, USA.
⁸Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
⁹Department of Microbiology, Immunology, and Biochemistry, Wayne State University School of Medicine, Detroit, MI 48201, USA.
¹⁰Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA.
¹¹Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.
¹²Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
¹³Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, CA 94143, USA.

↵*Corresponding author. Email: tippi.mackenzie{at}ucsf.edu

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Science Translational Medicine 25 Apr 2018:
Vol. 10, Issue 438, eaan2263
DOI: 10.1126/scitranslmed.aan2263

Michela Frascoli

1Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Lacy Coniglio

1Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Russell Witt

1Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Cerine Jeanty

1Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Shannon Fleck-Derderian

3Department of Pediatrics, University of California, San Francisco, CA 94143, USA.

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Dana E. Myers

4Obstetrics and Gynecology, University of California, San Francisco, CA 94143, USA.

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Tzong-Hae Lee

5Blood Systems Research Institute, San Francisco, CA 94118, USA.

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Sheila Keating

5Blood Systems Research Institute, San Francisco, CA 94118, USA.

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Michael P. Busch

5Blood Systems Research Institute, San Francisco, CA 94118, USA.

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Philip J. Norris

5Blood Systems Research Institute, San Francisco, CA 94118, USA.

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Qizhi Tang

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

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Giovanna Cruz

6Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA.

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Lisa F. Barcellos

6Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA.

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Nardhy Gomez-Lopez

7Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD)/National Institutes of Health (NIH)/U.S. Department of Health and Human Services (DHHS), Bethesda, MD 20892, USA.

8Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

9Department of Microbiology, Immunology, and Biochemistry, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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Roberto Romero

10Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA.

11Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.

12Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

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Tippi C. MacKenzie

1Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2Department of Surgery, University of California, San Francisco, CA 94143, USA.

13Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, CA 94143, USA.

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ORCID record for Tippi C. MacKenzie
For correspondence: tippi.mackenzie@ucsf.edu

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Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

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