Research ArticleHIV

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells

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Science Translational Medicine  18 Apr 2018:
Vol. 10, Issue 437, eaar6759
DOI: 10.1126/scitranslmed.aar6759

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  • RE:CD4+ T cells: Is there a role for CD32a in HIV-1 enrichment?
    • Anil K Chauhan, Associate Professor of Internal Medicine, Saint Louis University School of Medicine

    The role of Fc receptors (FcRs) play in the CD4+ T cells biology is unresolved (1). Now, the article by Abdel-Mohsen et. al. contends that a subset of the activated CD4+ T cells, which express CD32a enrich for transcriptionally active infection, cell associated HIV RNA after long-term antiretroviral therapy (ART) (2). This study follows two previous reports that also contend the association of CD32a with replication-competent HIV provirus in CD4+ T cells (3, 4). Descours study suggests that the CD32a is a highly specific surface marker for HIV-1 infected resting CD4+ T cells and a quiescence-dependent mechanism is required for CD32a expression. Both CD32aint and CD32ahi populations show viral enrichment, and the CD32ahi subset show higher HIV-1 enrichment. These studies are novel, however there are several unanswered questions and the conclusions are drawn based on the correlative data. Polyclonal stimulation of T-cell receptor (TCR) resulted in the induction of CD32a expression, virus production and its spread in cultures (2, 3). The role of immune complexes, CD32a ligand has not been examined or discussed by either study. To establish the role for CD32a in HIV biology, it is important to examine whether the engagement of CD32a by ICs result in productive HIV-1 infection, and the enrichment of HIV-1 DNA+ in CD4+ effector T cells. A critical question is whether the CD32a+ and HIV-1 enriched pool contributes to CD32- HIV-1 pool due to the loss of CD32a. HIV virus latency ca...

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    Competing Interests: None declared.

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