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Research ArticleCancer
Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target
- View ORCID ProfileDabin Liu1,
- Chi Chun Wong1,
- View ORCID ProfileLi Fu1,2,
- Huarong Chen1,
- Liuyang Zhao1,
- Chuangen Li1,
- Yunfei Zhou1,
- Yanquan Zhang1,
- Weiqi Xu1,
- Yidong Yang3,
- View ORCID ProfileBin Wu3,
- Gong Cheng4,
- Paul Bo-San Lai4,
- Nathalie Wong5,
- Joseph J. Y. Sung1 and
- View ORCID ProfileJun Yu1,*
- 1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
- 2Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Department of Pharmacology and Cancer Research Centre, School of Medicine, Shenzhen University, Shenzhen 518060, China.
- 3Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
- 4Department of Surgery, The Chinese University of Hong Kong, 999077, Hong Kong.
- 5Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 999077, Hong Kong.
- ↵*Corresponding author. Email: junyu{at}cuhk.edu.hk
See allHide authors and affiliations
Science Translational Medicine 18 Apr 2018:
Vol. 10, Issue 437, eaap9840
DOI: 10.1126/scitranslmed.aap9840
Vol. 10, Issue 437, eaap9840
DOI: 10.1126/scitranslmed.aap9840
Dabin Liu
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Chi Chun Wong
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Li Fu
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
2Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Department of Pharmacology and Cancer Research Centre, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Huarong Chen
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Liuyang Zhao
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Chuangen Li
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Yunfei Zhou
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Yanquan Zhang
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Weiqi Xu
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Yidong Yang
3Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Bin Wu
3Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Gong Cheng
4Department of Surgery, The Chinese University of Hong Kong, 999077, Hong Kong.
Paul Bo-San Lai
4Department of Surgery, The Chinese University of Hong Kong, 999077, Hong Kong.
Nathalie Wong
5Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 999077, Hong Kong.
Joseph J. Y. Sung
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
Jun Yu
1Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, 999077, Hong Kong.
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