18 April 2018
Vol 10, Issue 437

About The Cover

Cover image expansion

ONLINE COVER Squelching Squalene Stalls Cancer. Nonalcoholic fatty liver disease, exemplified by the liver shown in this image, is typically associated with obesity and is becoming increasingly common. A particularly dreaded complication of this disease is liver cancer, which is difficult to treat. By examining the role of cholesterol in the evolution of this condition, Liu et al. identified the contribution of squalene epoxidase, an enzyme involved in cholesterol metabolism. The authors showed that terbinafine, a common antifungal drug, can target squalene epoxidase and prevent progression to cancer in mouse models of nonalcoholic fatty liver disease. [CREDIT: CNRI/SCIENCE SOURCE]