Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

Janos L. Tanyi; Sara Bobisse; Eran Ophir; Sandra Tuyaerts; Annalisa Roberti; Raphael Genolet; Petra Baumgartner; Brian J. Stevenson; Christian Iseli; Denarda Dangaj; Brian Czerniecki; Aikaterini Semilietof; Julien Racle; Alexandra Michel; Ioannis Xenarios; Cheryl Chiang; Dimitri S. Monos; Drew A. Torigian; Harvey L. Nisenbaum; Olivier Michielin; Carl H. June; Bruce L. Levine; Daniel J. Powell; David Gfeller; Rosemarie Mick; Urania Dafni; Vincent Zoete; Alexandre Harari; George Coukos; Lana E. Kandalaft

doi:10.1126/scitranslmed.aao5931

Research ArticleCancer

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

View ORCID ProfileJanos L. Tanyi¹,*,
Sara Bobisse²,*,
Eran Ophir²,*,
View ORCID ProfileSandra Tuyaerts²,
View ORCID ProfileAnnalisa Roberti¹,
View ORCID ProfileRaphael Genolet²,
Petra Baumgartner²,
Brian J. Stevenson³,
View ORCID ProfileChristian Iseli³,
Denarda Dangaj²,
View ORCID ProfileBrian Czerniecki⁴,
View ORCID ProfileAikaterini Semilietof²,
View ORCID ProfileJulien Racle²,³,
Alexandra Michel²,
View ORCID ProfileIoannis Xenarios³,
View ORCID ProfileCheryl Chiang¹,
Dimitri S. Monos⁵,
Drew A. Torigian⁶,
View ORCID ProfileHarvey L. Nisenbaum⁶,
Olivier Michielin²,³,
View ORCID ProfileCarl H. June⁷,
View ORCID ProfileBruce L. Levine⁷,
Daniel J. Powell Jr.¹,
View ORCID ProfileDavid Gfeller²,³,
Rosemarie Mick⁸,
View ORCID ProfileUrania Dafni⁹,
Vincent Zoete²,³,
Alexandre Harari²,†,
View ORCID ProfileGeorge Coukos¹,²,† and
View ORCID ProfileLana E. Kandalaft¹,²,†,‡

¹Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.
³Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.
⁴Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
⁵Immunogenetics Laboratory, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
⁶Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁹Laboratory of Biostatistics, School of Health Sciences, National and Kapodistrian, University of Athens, Athens, Greece.

↵‡Corresponding author. Email: lana.kandalaft{at}chuv.ch

↵* These authors contributed equally to this work.
↵† These authors provided equal supervision to this work.

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Science Translational Medicine 11 Apr 2018:
Vol. 10, Issue 436, eaao5931
DOI: 10.1126/scitranslmed.aao5931

Janos L. Tanyi

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Sara Bobisse

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Eran Ophir

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Sandra Tuyaerts

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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ORCID record for Sandra Tuyaerts

Annalisa Roberti

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Raphael Genolet

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Petra Baumgartner

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Brian J. Stevenson

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Christian Iseli

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Denarda Dangaj

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Brian Czerniecki

4Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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Aikaterini Semilietof

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Julien Racle

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Alexandra Michel

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Ioannis Xenarios

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Cheryl Chiang

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Dimitri S. Monos

5Immunogenetics Laboratory, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Drew A. Torigian

6Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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Harvey L. Nisenbaum

6Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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Olivier Michielin

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Carl H. June

7Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Bruce L. Levine

7Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Daniel J. Powell Jr.

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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David Gfeller

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Rosemarie Mick

8Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Urania Dafni

9Laboratory of Biostatistics, School of Health Sciences, National and Kapodistrian, University of Athens, Athens, Greece.

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Vincent Zoete

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

3Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Alexandre Harari

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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George Coukos

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Lana E. Kandalaft

1Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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For correspondence: lana.kandalaft@chuv.ch

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