Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

Janos L. Tanyi; Sara Bobisse; Eran Ophir; Sandra Tuyaerts; Annalisa Roberti; Raphael Genolet; Petra Baumgartner; Brian J. Stevenson; Christian Iseli; Denarda Dangaj; Brian Czerniecki; Aikaterini Semilietof; Julien Racle; Alexandra Michel; Ioannis Xenarios; Cheryl Chiang; Dimitri S. Monos; Drew A. Torigian; Harvey L. Nisenbaum; Olivier Michielin; Carl H. June; Bruce L. Levine; Daniel J. Powell; David Gfeller; Rosemarie Mick; Urania Dafni; Vincent Zoete; Alexandre Harari; George Coukos; Lana E. Kandalaft

doi:10.1126/scitranslmed.aao5931

Research ArticleCancer

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

Janos L. Tanyi¹,*,
Sara Bobisse²,*,
Eran Ophir²,*,
Sandra Tuyaerts²,
Annalisa Roberti¹,
Raphael Genolet²,
Petra Baumgartner²,
Brian J. Stevenson³,
Christian Iseli³,
Denarda Dangaj²,
Brian Czerniecki⁴,
Aikaterini Semilietof²,
Julien Racle²,³,
Alexandra Michel²,
Ioannis Xenarios³,
Cheryl Chiang¹,
Dimitri S. Monos⁵,
Drew A. Torigian⁶,
Harvey L. Nisenbaum⁶,
Olivier Michielin²,³,
Carl H. June⁷,
Bruce L. Levine⁷,
Daniel J. Powell Jr.¹,
David Gfeller²,³,
Rosemarie Mick⁸,
Urania Dafni⁹,
Vincent Zoete²,³,
Alexandre Harari²,†,
George Coukos¹,²,† and
Lana E. Kandalaft¹,²,†,‡

¹Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.
³Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.
⁴Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
⁵Immunogenetics Laboratory, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
⁶Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
⁷Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁹Laboratory of Biostatistics, School of Health Sciences, National and Kapodistrian, University of Athens, Athens, Greece.

↵‡Corresponding author. Email: lana.kandalaft{at}chuv.ch

↵* These authors contributed equally to this work.
↵† These authors provided equal supervision to this work.

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Science Translational Medicine 11 Apr 2018:
Vol. 10, Issue 436, eaao5931
DOI: 10.1126/scitranslmed.aao5931

Janos L. Tanyi

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Sara Bobisse

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Eran Ophir

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Sandra Tuyaerts

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Annalisa Roberti

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Raphael Genolet

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Petra Baumgartner

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Brian J. Stevenson

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Christian Iseli

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Denarda Dangaj

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Brian Czerniecki

Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

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Aikaterini Semilietof

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Julien Racle

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Alexandra Michel

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Ioannis Xenarios

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Cheryl Chiang

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Dimitri S. Monos

Immunogenetics Laboratory, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Drew A. Torigian

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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Harvey L. Nisenbaum

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

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Olivier Michielin

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Carl H. June

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Bruce L. Levine

Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Daniel J. Powell Jr.

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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David Gfeller

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Rosemarie Mick

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Urania Dafni

Laboratory of Biostatistics, School of Health Sciences, National and Kapodistrian, University of Athens, Athens, Greece.

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Vincent Zoete

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

Swiss Institute of Bioinformatics, Lausanne CH-1015, Switzerland.

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Alexandre Harari

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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George Coukos

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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Lana E. Kandalaft

Ovarian Cancer Research Center, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Department of Oncology, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne CH-1066, Switzerland.

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For correspondence: lana.kandalaft@chuv.ch

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Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

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