Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Luis A. Carvajal; Daniela Ben Neriah; Adrien Senecal; Lumie Benard; Victor Thiruthuvanathan; Tatyana Yatsenko; Swathi-Rao Narayanagari; Justin C. Wheat; Tihomira I. Todorova; Kelly Mitchell; Charles Kenworthy; Vincent Guerlavais; D. Allen Annis; Boris Bartholdy; Britta Will; Jesus D. Anampa; Ioannis Mantzaris; Manuel Aivado; Robert H. Singer; Robert A. Coleman; Amit Verma; Ulrich Steidl

doi:10.1126/scitranslmed.aao3003

Research ArticleCancer

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Luis A. Carvajal¹,
Daniela Ben Neriah¹,
Adrien Senecal²,
Lumie Benard¹,
Victor Thiruthuvanathan¹,
Tatyana Yatsenko¹,
Swathi-Rao Narayanagari¹,³,
Justin C. Wheat¹,
Tihomira I. Todorova¹,
Kelly Mitchell¹,
Charles Kenworthy²,
Vincent Guerlavais⁴,
D. Allen Annis⁴,
Boris Bartholdy¹,
Britta Will¹,³,⁵,⁶,
Jesus D. Anampa⁵,
Ioannis Mantzaris⁵,
Manuel Aivado⁴,
Robert H. Singer²,
Robert A. Coleman²,
Amit Verma³,⁵,⁶ and
Ulrich Steidl ¹,³,⁵,⁶,*

¹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
²Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
³Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
⁴Aileron Therapeutics, Cambridge, MA 02139, USA.
⁵Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
⁶Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

↵*Corresponding author. Email: ulrich.steidl{at}einstein.yu.edu

See allHide authors and affiliations

Science Translational Medicine 11 Apr 2018:
Vol. 10, Issue 436, eaao3003
DOI: 10.1126/scitranslmed.aao3003

Luis A. Carvajal

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Luis A. Carvajal

Daniela Ben Neriah

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Adrien Senecal

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Adrien Senecal

Lumie Benard

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lumie Benard

Victor Thiruthuvanathan

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Victor Thiruthuvanathan

Tatyana Yatsenko

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tatyana Yatsenko

Swathi-Rao Narayanagari

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Swathi-Rao Narayanagari

Justin C. Wheat

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Justin C. Wheat

Tihomira I. Todorova

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tihomira I. Todorova

Kelly Mitchell

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kelly Mitchell

Charles Kenworthy

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vincent Guerlavais

Aileron Therapeutics, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

D. Allen Annis

Aileron Therapeutics, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Boris Bartholdy

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Britta Will

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jesus D. Anampa

Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jesus D. Anampa

Ioannis Mantzaris

Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Manuel Aivado

Aileron Therapeutics, Cambridge, MA 02139, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert H. Singer

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Robert H. Singer

Robert A. Coleman

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Robert A. Coleman

Amit Verma

Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ulrich Steidl

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ulrich Steidl
For correspondence: ulrich.steidl@einstein.yu.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools