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Research ArticleCancer
Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
- View ORCID ProfileLuis A. Carvajal1,
- Daniela Ben Neriah1,
- View ORCID ProfileAdrien Senecal2,
- View ORCID ProfileLumie Benard1,
- View ORCID ProfileVictor Thiruthuvanathan1,
- View ORCID ProfileTatyana Yatsenko1,
- View ORCID ProfileSwathi-Rao Narayanagari1,3,
- View ORCID ProfileJustin C. Wheat1,
- View ORCID ProfileTihomira I. Todorova1,
- View ORCID ProfileKelly Mitchell1,
- Charles Kenworthy2,
- Vincent Guerlavais4,
- D. Allen Annis4,
- Boris Bartholdy1,
- Britta Will1,3,5,6,
- View ORCID ProfileJesus D. Anampa5,
- Ioannis Mantzaris5,
- Manuel Aivado4,
- View ORCID ProfileRobert H. Singer2,
- View ORCID ProfileRobert A. Coleman2,
- Amit Verma3,5,6 and
- View ORCID ProfileUlrich Steidl1,3,5,6,*
- 1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 2Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 3Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 4Aileron Therapeutics, Cambridge, MA 02139, USA.
- 5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 6Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- ↵*Corresponding author. Email: ulrich.steidl{at}einstein.yu.edu
See allHide authors and affiliations
Science Translational Medicine 11 Apr 2018:
Vol. 10, Issue 436, eaao3003
DOI: 10.1126/scitranslmed.aao3003
Vol. 10, Issue 436, eaao3003
DOI: 10.1126/scitranslmed.aao3003
Luis A. Carvajal
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Daniela Ben Neriah
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Adrien Senecal
2Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lumie Benard
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Victor Thiruthuvanathan
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Tatyana Yatsenko
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Swathi-Rao Narayanagari
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Justin C. Wheat
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Tihomira I. Todorova
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kelly Mitchell
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Charles Kenworthy
2Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vincent Guerlavais
4Aileron Therapeutics, Cambridge, MA 02139, USA.
D. Allen Annis
4Aileron Therapeutics, Cambridge, MA 02139, USA.
Boris Bartholdy
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Britta Will
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
6Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jesus D. Anampa
5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Ioannis Mantzaris
5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Manuel Aivado
4Aileron Therapeutics, Cambridge, MA 02139, USA.
Robert H. Singer
2Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Robert A. Coleman
2Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Amit Verma
3Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
6Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Ulrich Steidl
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
5Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY 10461, USA.
6Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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