11 April 2018
Vol 10, Issue 436
  • Review

  • Research Articles

    • Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

      Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia.

    • The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

      Anti-inflammatories prevent surgery-induced outgrowth of distant tumors in mouse models and may reduce early metastatic relapse in patients.

    • T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

      T cells promote immunosuppression in melanoma through CSF1 induction and macrophage recruitment.

    • Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

      Personalized cancer vaccines induce antitumor T cells that correlate with clinical benefit in patients with ovarian cancer.

    • Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

      Thrombosis in myeloproliferative neoplasms is associated with increased NETosis that can be targeted with JAK inhibitors.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER The Battle Within. This image depicts the body's struggle against cancer as a stand-off between tumor cell soldiers huddled in the center of the drawing and immune cell soldiers closing in for the final battle. Coinciding with the annual conference of the American Association for Cancer Research, this issue's Focus on Cancer includes a collection of articles on immune- and non-immune-based advances in combating a variety of cancer types. [CREDIT: DAVIDE BONAZZI/@SALZMANART]