Contents

Research Articles

• Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

  By Luis A. Carvajal, Daniela Ben Neriah, Adrien Senecal, Lumie Benard, Victor Thiruthuvanathan, Tatyana Yatsenko, Swathi-Rao Narayanagari, Justin C. Wheat, Tihomira I. Todorova, Kelly Mitchell, Charles Kenworthy, Vincent Guerlavais, D. Allen Annis, Boris Bartholdy, Britta Will, Jesus D. Anampa, Ioannis Mantzaris, Manuel Aivado, Robert H. Singer, Robert A. Coleman, Amit Verma, Ulrich Steidl

  Science Translational Medicine11 Apr 2018 Full AccessRestricted Access

  Dual inhibition of MDMX and MDM2 by an α-helical p53-stapled peptide (ALRN-6924) results in robust antitumor activity in acute myeloid leukemia.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials

• The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

  By Jordan A. Krall, Ferenc Reinhardt, Oblaise A. Mercury, Diwakar R. Pattabiraman, Mary W. Brooks, Michael Dougan, Arthur W. Lambert, Brian Bierie, Hidde L. Ploegh, Stephanie K. Dougan, Robert A. Weinberg

  Science Translational Medicine11 Apr 2018 Full AccessRestricted Access

  Anti-inflammatories prevent surgery-induced outgrowth of distant tumors in mouse models and may reduce early metastatic relapse in patients.

  • Editor's Summary
  • Abstract
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• T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

  By Natalie J. Neubert, Martina Schmittnaegel, Natacha Bordry, Sina Nassiri, Noémie Wald, Christophe Martignier, Laure Tillé, Krisztian Homicsko, William Damsky, Hélène Maby-El Hajjami, Irina Klaman, Esther Danenberg, Kalliopi Ioannidou, Lana Kandalaft, George Coukos, Sabine Hoves, Carola H. Ries, Silvia A. Fuertes Marraco, Periklis G. Foukas, Michele De Palma, Daniel E. Speiser

  Science Translational Medicine11 Apr 2018 Full AccessRestricted Access

  T cells promote immunosuppression in melanoma through CSF1 induction and macrophage recruitment.

  • Editor's Summary
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• Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

  By Janos L. Tanyi, Sara Bobisse, Eran Ophir, Sandra Tuyaerts, Annalisa Roberti, Raphael Genolet, Petra Baumgartner, Brian J. Stevenson, Christian Iseli, Denarda Dangaj, Brian Czerniecki, Aikaterini Semilietof, Julien Racle, Alexandra Michel, Ioannis Xenarios, Cheryl Chiang, Dimitri S. Monos, Drew A. Torigian, Harvey L. Nisenbaum, Olivier Michielin, Carl H. June, Bruce L. Levine, Daniel J. Powell, Jr., David Gfeller, Rosemarie Mick, Urania Dafni, Vincent Zoete, Alexandre Harari, George Coukos, Lana E. Kandalaft

  Science Translational Medicine11 Apr 2018 Full AccessRestricted Access

  Personalized cancer vaccines induce antitumor T cells that correlate with clinical benefit in patients with ovarian cancer.

  • Editor's Summary
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• Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

  By Ofir Wolach, Rob S. Sellar, Kimberly Martinod, Deya Cherpokova, Marie McConkey, Ryan J. Chappell, Alexander J. Silver, Dylan Adams, Cecilia A. Castellano, Rebekka K. Schneider, Robert F. Padera, Daniel J. DeAngelo, Martha Wadleigh, David P. Steensma, Ilene Galinsky, Richard M. Stone, Giulio Genovese, Steven A. McCarroll, Bozenna Iliadou, Christina Hultman, Donna Neuberg, Ann Mullally, Denisa D. Wagner, Benjamin L. Ebert

  Science Translational Medicine11 Apr 2018 Full AccessRestricted Access

  Thrombosis in myeloproliferative neoplasms is associated with increased NETosis that can be targeted with JAK inhibitors.

  • Editor's Summary
  • Abstract
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  • Supplementary Materials