Contents
04 April 2018
Vol 10, Issue 435
Vol 10, Issue 435
Research Articles
- A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration
Implantation of a human embryonic stem cell–derived retinal pigment epithelial monolayer is feasible in human subjects with advanced, dry age-related macular degeneration.
- Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia
IP6K1-mediated polyP production by platelets promotes neutrophil-platelet aggregation and neutrophil accumulation in bacterial pneumonia.
- Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques
Zika virus infection early after birth has deleterious effects on the developing brain and long-term behavioral changes in rhesus macaques.
- Battery-free, wireless sensors for full-body pressure and temperature mapping
Battery-free, soft, skin-mounted wireless sensors enable continuous, full-body spatiotemporal mapping of pressure and temperature on human subjects.
- Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data
A rabbit model of pulmonary cavitary tuberculosis helps to explain phase 2 clinical trial results for the rifamycin class of TB drugs.
Review
- Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease
Differentiation of human pluripotent stem cells into cardiomyocytes and other cardiac cells enables modeling of heart function and elucidation of disease pathogenesis.
Editors' Choice
- Fighting leukemia with “duel”-targeted therapy
Combining BCL-2 inhibitor venetoclax with monoclonal CD20 antibody rituximab greatly enhances progression-free survival compared with bendamustine-rituximab in a phase 3 trial of relapsed or refractory chronic lymphocytic leukemia patients.
- Overlooking cardiac dysfunction triggered by immune checkpoint inhibitors: Caution, trespassers will be ventilated
Immune-related cardiac adverse events can ensue following immunotherapies.
- Targeting a conserved epitope: A new chink in malaria’s armor
Human monoclonal antibodies targeting a specific epitope of the antigen from Plasmodium falciparum show protection in mice and may offer long-lasting therapies against malaria.
Erratum
About The Cover
ONLINE COVER Illuminating New Treatments for Blinding Diseases. Shown is a retinal fundus photograph of the retina of a patient with the blinding disease advanced dry age-related macular degeneration (AMD). This patient underwent minimally invasive surgery to receive a tissue-engineered retinal pigment epithelium monolayer developed by Kashani et al. with the goal of replacing retinal cells lost due to AMD. The image shows the tissue engineered implant on the patient's retina 90 days after surgery. Kashani et al. have implanted four patients with AMD so far, and the implant was found to be safe and well tolerated for up to 1 year after surgery. [CREDIT: KASHANI ET AL./SCIENCE TRANSLATIONAL MEDICINE]