A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever

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Science Translational Medicine  28 Mar 2018:
Vol. 10, Issue 434, eaaq1016
DOI: 10.1126/scitranslmed.aaq1016

An enlightening Ebola model

Using large doses of highly pathogenic agents in animal models can ensure consistent and fully penetrant infection but does not recapitulate human exposure and possibly immune responses. Speranza and colleagues intranasally infected cynomolgus macaques with a small dose of Ebola virus, which led to various disease presentation and allowed for detection of early immunity. Regardless of the timing of symptoms, analysis of the host response revealed a conserved interferon signature that preceded fever by several days. These results shed light on the host response to Ebola virus and established a model that could be used for future studies of pathogenesis, treatment, or prevention.

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