Research ArticleHeart Failure

Ablation of the stress protease OMA1 protects against heart failure in mice

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Science Translational Medicine  28 Mar 2018:
Vol. 10, Issue 434, eaan4935
DOI: 10.1126/scitranslmed.aan4935

A mitochondrial mark for heart failure

Current therapies for heart failure vary depending on the root cause and stage of the disease. Acin-Perez et al. studied the molecular link between mitochondrial dysfunction and heart failure, focusing on OMA1, a protease involved in mitochondrial inner membrane remodeling and cytochrome c release. Using three mouse models of heart failure, they found that cardiomyocytes were protected from mitochondrial reactive oxygen species–induced cell death when OMA1 was ablated. OMA1 could be a therapeutic target for heart failure.

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