Research ArticleEpidemiology

Vaccine waning and mumps re-emergence in the United States

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Science Translational Medicine  21 Mar 2018:
Vol. 10, Issue 433, eaao5945
DOI: 10.1126/scitranslmed.aao5945

The mystery of mumps resurgence

Rising mumps cases in vaccinated populations in the United States over the past decade have raised doubts about mumps vaccine efficacy. Here, Lewnard et al. examined these outbreaks using mumps vaccine effectiveness data and dynamic transmission modeling. They found that the increase in mumps cases is more consistent with loss of vaccine protection over time, rather than incomplete protection against an evolving virus population or lack of immune response to the vaccine. Their work also suggested that a third vaccine dose may extend protection, which could prove useful in designing a clinical action plan to prevent the spread of mumps.

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