Research ArticleHEPATITIS

An OX40/OX40L interaction directs successful immunity to hepatitis B virus

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Science Translational Medicine  21 Mar 2018:
Vol. 10, Issue 433, eaah5766
DOI: 10.1126/scitranslmed.aah5766

Hepatitis immunity: Better with age

Hepatitis B virus (HBV) infection can have severe complications, including cirrhosis and cancer. Most chronic HBV patients are infected at an early age, as adults can readily clear the virus. Publicover et al. used a mouse model of age-dependent HBV clearance and samples from patients to study the mechanisms leading to effective immunity in adults. They discovered that OX40 ligand expression in hepatic immune cells increases with age and is important for viral control. These results clarify some of the chronological differences in the immune response and also suggest that boosting OX40 activity in infants and chronically-infected adults could promote effective HBV immunity.

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