Research ArticleStroke
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke
- Stefan Roth1,2,
- Vikramjeet Singh1,2,
- Steffen Tiedt1,2,
- Lisa Schindler1,2,
- Georg Huber3,
- Arie Geerlof3,
- Daniel J. Antoine4,
- Antoine Anfray5,
- Cyrille Orset5,
- Maxime Gauberti5,
- Antoine Fournier5,
- Lesca M. Holdt6,
- Helena Erlandsson Harris7,
- Britta Engelhardt8,
- Marco E. Bianchi9,
- Denis Vivien5,
- Christof Haffner1,
- Jürgen Bernhagen1,2,
- Martin Dichgans1,2 and
- Arthur Liesz1,2,*
- 1Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.
- 2Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
- 3Institute of Structural Biology, Helmholtz Centre Munich, 85764 Munich, Germany.
- 4Medical Research Council Center for Drug Safety Science, Department for Molecular and Clinical Pharmacology, University of Liverpool, L69 3GE Liverpool, UK.
- 5INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
- 6Institute of Laboratory Medicine, Klinikum der Universität München, 81377 Munich, Germany.
- 7Department of Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
- 8Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3012 Bern, Switzerland.
- 9Faculty of Medicine, San Raffaele University, 20132, Milan, Italy.
- ↵*Corresponding author. Email: arthur.liesz{at}med.uni-muenchen.de
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Science Translational Medicine 14 Mar 2018:
Vol. 10, Issue 432, eaao1313
DOI: 10.1126/scitranslmed.aao1313
Vol. 10, Issue 432, eaao1313
DOI: 10.1126/scitranslmed.aao1313
Stefan Roth
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Vikramjeet Singh
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Steffen Tiedt
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Lisa Schindler
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Georg Huber
Institute of Structural Biology, Helmholtz Centre Munich, 85764 Munich, Germany.
Arie Geerlof
Institute of Structural Biology, Helmholtz Centre Munich, 85764 Munich, Germany.
Daniel J. Antoine
Medical Research Council Center for Drug Safety Science, Department for Molecular and Clinical Pharmacology, University of Liverpool, L69 3GE Liverpool, UK.
Antoine Anfray
INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
Cyrille Orset
INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
Maxime Gauberti
INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
Antoine Fournier
INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
Lesca M. Holdt
Institute of Laboratory Medicine, Klinikum der Universität München, 81377 Munich, Germany.
Helena Erlandsson Harris
Department of Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Britta Engelhardt
Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3012 Bern, Switzerland.
Marco E. Bianchi
Faculty of Medicine, San Raffaele University, 20132, Milan, Italy.
Denis Vivien
INSERM, Université de Caen-Normandie, CHU de Caen, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, 14074 Caen, France.
Christof Haffner
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.
Jürgen Bernhagen
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Martin Dichgans
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
Arthur Liesz
Institute for Stroke and Dementia Research, Klinikum der Universität München, 81377 Munich, Germany.Munich Cluster for System Neurology (SyNergy), 80336 Munich, Germany.
