Research ArticleWound Healing

The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing

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Science Translational Medicine  14 Mar 2018:
Vol. 10, Issue 432, eaai8524
DOI: 10.1126/scitranslmed.aai8524

Secreting cytokines to correct cuts

Wound healing is a multi-phase process encompassing inflammation, cell proliferation, and the deposition and remodeling of extracellular matrix. To understand the molecular signaling pathways contributing to this process, Kou et al. studied cytokine secretion during wound healing. They found that mesenchymal stem cells secrete extracellular vesicles via a caveolin-1–mediated exocytotic process and produce interleukin-1 receptor antagonist (IL-1RA) during gingival and cutaneous wound healing in mice. Treating wounds with recombinant IL-1RA or small extracellular vesicles expressing IL-1RA accelerated wound healing. This signaling pathway could be targeted to develop wound healing therapies.

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