14 March 2018
Vol 10, Issue 432

About The Cover

Cover image expansion

ONLINE COVER Switching Off the Alarm. One of the adverse consequences of a stroke is the increased risk of developing subsequent atherosclerosis-associated cardiovascular events. Depicted here is the activation of an alarm illustrating the study by Roth et al. These authors found that stroke-induced release of the alarmin HMGB1 and activation of the sympathetic stress response synergize to exacerbate atherosclerosis in mice. The investigators also showed that neutralization of circulating alarmins after stroke might have potential benefit in reducing the risk of cardiovascular events after stroke. [CREDIT: RUSSELLTATEdotCOM/ISTOCKPHOTO]