Contents
14 March 2018
Vol 10, Issue 432
Vol 10, Issue 432
Research Articles
- Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke
Atherosclerosis is exacerbated after stroke because of synergy of catecholaminergic stress response and alarmin-dependent signaling.
- Illusory movement perception improves motor control for prosthetic hands
A perceptual illusion provides the sensation of complex bionic hand movements to human amputees, allowing real-time movement control without the necessity of vision.
- The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing
Mesenchymal stem cells use the Fas/Fap-1/Cav-1 axis to control vesicle and cytokine secretion to accelerate wound healing in mice.
- Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2
Targeting IL-6 and potentially FGF-2 overcomes resistance to anti-VEGF therapy in breast cancer.
- Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions
Multimodal mass spectrometric imaging identifies bacterial and host analytes in intact tissues during invasive infection in mice.
Editors' Choice
- The long(er) road from brain to meninges
Medulloblastoma spreads from the cerebellum to the leptomeninges via blood in addition to cerebrospinal fluid.
- Dieting bacteria cure fatty liver disease
Lowering carbohydrate intake treats fatty liver disease in humans by changing gut microbial composition and metabolism.
- Distressing microbial consequences of smoking
Changes in lung microbiota associated with smoking might contribute to the development of acute respiratory distress syndrome in subjects with blunt trauma.
About The Cover
ONLINE COVER Switching Off the Alarm. One of the adverse consequences of a stroke is the increased risk of developing subsequent atherosclerosis-associated cardiovascular events. Depicted here is the activation of an alarm illustrating the study by Roth et al. These authors found that stroke-induced release of the alarmin HMGB1 and activation of the sympathetic stress response synergize to exacerbate atherosclerosis in mice. The investigators also showed that neutralization of circulating alarmins after stroke might have potential benefit in reducing the risk of cardiovascular events after stroke. [CREDIT: RUSSELLTATEdotCOM/ISTOCKPHOTO]
