A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

Xilin Sun; Zunyu Xiao; Gongyan Chen; Zhaoguo Han; Yang Liu; Chongqing Zhang; Yingying Sun; Yan Song; Kai Wang; Fang Fang; Xiance Wang; Yanhong Lin; Lili Xu; Liming Shao; Jin Li; Zhen Cheng; Sanjiv Sam Gambhir; Baozhong Shen

doi:10.1126/scitranslmed.aan8840

Research ArticleCancer

A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

View ORCID ProfileXilin Sun¹,²,³,
Zunyu Xiao¹,
Gongyan Chen⁴,
Zhaoguo Han¹,
Yang Liu¹,
Chongqing Zhang¹,
Yingying Sun²,
Yan Song¹,
Kai Wang¹,²,
Fang Fang²,
Xiance Wang¹,
Yanhong Lin¹,
Lili Xu⁵,
Liming Shao⁵,
View ORCID ProfileJin Li⁶,
View ORCID ProfileZhen Cheng³,*,
View ORCID ProfileSanjiv Sam Gambhir³,* and
View ORCID ProfileBaozhong Shen¹,²,*

¹Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.
²TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.
³Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁴Department of Respiratory Medical Oncology, The Tumor Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang 150049, China.
⁵School of Pharmacy, Fudan University, Shanghai 201203, China.
⁶College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.

↵*Corresponding author. Email: shenbz{at}ems.hrbmu.edu.cn (B.S.); sgambhir{at}stanford.edu (S.S.G.); zcheng{at}stanford.edu (Z.C.)

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Science Translational Medicine 07 Mar 2018:
Vol. 10, Issue 431, eaan8840
DOI: 10.1126/scitranslmed.aan8840

Xilin Sun

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

2TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

3Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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ORCID record for Xilin Sun

Zunyu Xiao

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Gongyan Chen

4Department of Respiratory Medical Oncology, The Tumor Hospital Affiliated Harbin Medical University, Harbin, Heilongjiang 150049, China.

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Zhaoguo Han

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Yang Liu

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Chongqing Zhang

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Yingying Sun

2TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

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Yan Song

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Kai Wang

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

2TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

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Fang Fang

2TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

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Xiance Wang

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Yanhong Lin

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

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Lili Xu

5School of Pharmacy, Fudan University, Shanghai 201203, China.

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Liming Shao

5School of Pharmacy, Fudan University, Shanghai 201203, China.

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Jin Li

6College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.

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Zhen Cheng

3Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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For correspondence: shenbz@ems.hrbmu.edu.cn sgambhir@stanford.edu zcheng@stanford.edu

Sanjiv Sam Gambhir

3Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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For correspondence: shenbz@ems.hrbmu.edu.cn sgambhir@stanford.edu zcheng@stanford.edu

Baozhong Shen

1Molecular Imaging Research Center, Harbin Medical University (MIRC), Harbin, Heilongjiang 150028, China.

2TOF-PET/CT/MR Center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang 150028, China.

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ORCID record for Baozhong Shen
For correspondence: shenbz@ems.hrbmu.edu.cn sgambhir@stanford.edu zcheng@stanford.edu

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¹⁸F-MPG PET/CT enables noninvasive identification of NSCLC patients who may benefit from EGFR-TKI therapy and can be used to monitor treatment outcome.

A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

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