Research ArticleMalaria

Malaria in pregnancy alters l-arginine bioavailability and placental vascular development

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Science Translational Medicine  07 Mar 2018:
Vol. 10, Issue 431, eaan6007
DOI: 10.1126/scitranslmed.aan6007

Article Information

vol. 10 no. 431

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  • Received for publication May 7, 2017
  • Resubmitted October 27, 2017
  • Accepted for publication December 15, 2017

Author Information

  1. Chloe R. McDonald1,2,
  2. Lindsay S. Cahill3,4,
  3. Joel L. Gamble2,
  4. Robyn Elphinstone2,
  5. Lisa M. Gazdzinski3,4,
  6. Kathleen J. Y. Zhong2,
  7. Adrienne C. Philson5,
  8. Mwayiwawo Madanitsa6,
  9. Linda Kalilani-Phiri6,
  10. Victor Mwapasa6,
  11. Feiko O. ter Kuile7,
  12. John G. Sled3,4,
  13. Andrea L. Conroy2,8 and
  14. Kevin C. Kain1,2,8,*
  1. 1Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  2. 2Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  3. 3Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3HT, Canada.
  4. 4Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  5. 5Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02138, USA.
  6. 6College of Medicine, University of Malawi, P.O. Box 280, Blantyre, Malawi.
  7. 7Liverpool School of Tropical Medicine, Liverpool L35QA, UK.
  8. 8Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario M5G 2C4, Canada.
  1. *Corresponding author. Email: kevin.kain{at}


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