Research ArticleHIV

HIV latency in isolated patient CD4+ T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing

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Science Translational Medicine  28 Feb 2018:
Vol. 10, Issue 430, eaap9927
DOI: 10.1126/scitranslmed.aap9927

Watching HIV in its hiding place

A barrier to developing a cure for HIV is the problem of viral latency, in which a small population of patient CD4+ T cells harbor inactive virus. These cells remain infected but untargetable by current antiretrovirals, meaning treatment must be lifelong. Now, Yukl et al. have identified and quantified multiple reversible blocks to HIV transcription in latently infected CD4+ T cells taken from infected patients on antiretroviral therapy. They found that viral transcription was stalled not at initiation but rather at downstream stages. These findings may be important for developing therapies to fully eradicate HIV infection.

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