Research ArticleCardiology

Mechanical circulatory support device-heart hysteretic interaction can predict left ventricular end diastolic pressure

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Science Translational Medicine  28 Feb 2018:
Vol. 10, Issue 430, eaao2980
DOI: 10.1126/scitranslmed.aao2980

Predicting pressure from a pump

Mechanical ventricular assist devices help the heart pump blood after cardiac surgery or while awaiting heart transplant. Chang et al. show that the motor current and pressure head recorded by the Impella, a temporary assist device placed within the left ventricle, can be used to measure left ventricular end diastolic pressure (LVEDP). LVEDP indicates cardiac function and is used to titrate mechanical pump support. Chang and colleagues found that Impella-based LVEDPs matched left heart catheter-based LVEDPs more closely than pulmonary capillary wedge pressure–inferred LVEDPs. After testing in a mock circulatory loop and a pig model of cardiac dysfunction, they confirmed their findings with patient data. This method does not require any modification of the Impella assist device, suggesting that it could be easily adopted into clinical practice.

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