Research ArticleTuberculosis
Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe
- View ORCID ProfileMireille Kamariza1,*,
- View ORCID ProfilePeyton Shieh2,*,
- Christopher S. Ealand3,
- View ORCID ProfileJulian S. Peters3,
- View ORCID ProfileBrian Chu2,
- Frances P. Rodriguez-Rivera2,
- View ORCID ProfileMohammed R. Babu Sait4,
- William V. Treuren5,
- Neil Martinson3,6,
- View ORCID ProfileRainer Kalscheuer4,
- View ORCID ProfileBavesh D. Kana3,7 and
- View ORCID ProfileCarolyn R. Bertozzi2,8,†
- 1Department of Biology, Stanford University, Stanford, CA 94305, USA.
- 2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
- 3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
- 4Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
- 5Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
- 6Perinatal HIV Research Unit (PHRU), SA MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa.
- 7Medical Research Council–Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa.
- 8Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
- ↵†Corresponding author. Email: bertozzi{at}stanford.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 28 Feb 2018:
Vol. 10, Issue 430, eaam6310
DOI: 10.1126/scitranslmed.aam6310
Vol. 10, Issue 430, eaam6310
DOI: 10.1126/scitranslmed.aam6310
Mireille Kamariza
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
Peyton Shieh
2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Christopher S. Ealand
3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
Julian S. Peters
3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
Brian Chu
2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Frances P. Rodriguez-Rivera
2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Mohammed R. Babu Sait
4Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
William V. Treuren
5Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Neil Martinson
3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
6Perinatal HIV Research Unit (PHRU), SA MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa.
Rainer Kalscheuer
4Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
Bavesh D. Kana
3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
7Medical Research Council–Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa.
Carolyn R. Bertozzi
2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
8Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
