Research ArticleTuberculosis
Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe
- Mireille Kamariza1,*,
- Peyton Shieh2,*,
- Christopher S. Ealand3,
- Julian S. Peters3,
- Brian Chu2,
- Frances P. Rodriguez-Rivera2,
- Mohammed R. Babu Sait4,
- William V. Treuren5,
- Neil Martinson3,6,
- Rainer Kalscheuer4,
- Bavesh D. Kana3,7 and
- Carolyn R. Bertozzi2,8,†
- 1Department of Biology, Stanford University, Stanford, CA 94305, USA.
- 2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
- 3Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
- 4Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
- 5Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
- 6Perinatal HIV Research Unit (PHRU), SA MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa.
- 7Medical Research Council–Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa.
- 8Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
- ↵†Corresponding author. Email: bertozzi{at}stanford.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 28 Feb 2018:
Vol. 10, Issue 430, eaam6310
DOI: 10.1126/scitranslmed.aam6310
Vol. 10, Issue 430, eaam6310
DOI: 10.1126/scitranslmed.aam6310
Mireille Kamariza
Department of Biology, Stanford University, Stanford, CA 94305, USA.
Peyton Shieh
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Christopher S. Ealand
Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
Julian S. Peters
Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
Brian Chu
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Frances P. Rodriguez-Rivera
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Mohammed R. Babu Sait
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
William V. Treuren
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Neil Martinson
Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.Perinatal HIV Research Unit (PHRU), SA MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa.
Rainer Kalscheuer
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Duesseldorf, Universitätsstrasse 1, 40225 Duesseldorf, Germany.
Bavesh D. Kana
Department of Science and Technology/National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.Medical Research Council–Centre for the AIDS Programme of Research in South Africa (CAPRISA) HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa.
Carolyn R. Bertozzi
Department of Chemistry, Stanford University, Stanford, CA 94305, USA.Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
