Research ArticleFibrosis

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis

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Science Translational Medicine  21 Feb 2018:
Vol. 10, Issue 429, eaan0333
DOI: 10.1126/scitranslmed.aan0333

Article Information

vol. 10 no. 429

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History: 
  • Received for publication February 22, 2017
  • Resubmitted October 5, 2017
  • Accepted for publication January 17, 2018
  • .

Author Information

  1. Naoki Takemura1,2,
  2. Yosuke Kurashima1,3,4,5,6,
  3. Yuki Mori7,
  4. Kazuki Okada8,
  5. Takayuki Ogino9,10,
  6. Hideki Osawa9,
  7. Hirosih Matsuno9,
  8. Lamichhane Aayam3,
  9. Satoshi Kaneto3,
  10. Eun Jeong Park3,11,
  11. Shintaro Sato3,12,
  12. Kouta Matsunaga2,
  13. Yusuke Tamura2,
  14. Yasuo Ouchi1,
  15. Yutaro Kumagai13,
  16. Daichi Kobayashi14,15,
  17. Yutaka Suzuki16,
  18. Yoshichika Yoshioka7,
  19. Junichi Nishimura9,
  20. Masaki Mori9,
  21. Ken J. Ishii17,18,
  22. Mark E. Rothenberg19,
  23. Hiroshi Kiyono3,6,20,
  24. Shizuo Akira21,22 and
  25. Satoshi Uematsu1,2,*
  1. 1Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
  2. 2Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
  3. 3Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  4. 4Institute for Global Prominent Research, Chiba University, Chiba 260-8670, Japan.
  5. 5Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
  6. 6Division of Clinical Vaccinology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
  7. 7Laboratory of Biofunctional Imaging, World Premier Institute (WPI) Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
  8. 8Immunology and Allergy R&D Unit, R&D Division, Kyowa Hakko Kirin Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
  9. 9Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
  10. 10Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Obere Zahlbacher Strasse 67, Mainz 55131, Germany.
  11. 11Department of Molecular Pathobiology and Cell Adhesion Biology, Basic Medical Sciences, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
  12. 12Mucosal Vaccine Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
  13. 13Quantitative Immunology Research Unit, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  14. 14Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
  15. 15Laboratory of Mucosal Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  16. 16Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan.
  17. 17Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, 7-6-8 Asagi Saito, Ibaraki, Osaka 567-0085, Japan.
  18. 18Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  19. 19Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  20. 20Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
  21. 21Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
  22. 22Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
  1. *Corresponding author. Email: suematsu{at}chiba-u.jp

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