Research ArticleDrug Discovery
High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds
- View ORCID ProfileMattia Zampieri1,*,†,
- View ORCID ProfileBalazs Szappanos1,2,*,
- View ORCID ProfileMaria Virginia Buchieri3,*,
- View ORCID ProfileAndrej Trauner4,5,
- Ilaria Piazza6,
- View ORCID ProfilePaola Picotti6,
- View ORCID ProfileSébastien Gagneux4,5,
- Sonia Borrell4,5,
- Brigitte Gicquel3,
- View ORCID ProfileJoel Lelievre7,
- View ORCID ProfileBalazs Papp2 and
- View ORCID ProfileUwe Sauer1
- 1Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
- 2Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
- 3Mycobacterial Genetics Unit, Institut Pasteur, 25-28 Rue du Docteur Roux, 75015 Paris, France.
- 4Swiss Tropical and Public Health Institute, Basel, Switzerland.
- 5University of Basel, Basel, Switzerland.
- 6Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland.
- 7Disease of the Developing World, GlaxoSmithKline, Severo Ochoa, Tres Cantos, Madrid 28760, Spain.
- ↵†Corresponding author. Email: zampieri{at}imsb.biol.ethz.ch
↵* These authors contributed equally to this work.
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Science Translational Medicine 21 Feb 2018:
Vol. 10, Issue 429, eaal3973
DOI: 10.1126/scitranslmed.aal3973
Vol. 10, Issue 429, eaal3973
DOI: 10.1126/scitranslmed.aal3973
Mattia Zampieri
1Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
Balazs Szappanos
1Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
2Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
Maria Virginia Buchieri
3Mycobacterial Genetics Unit, Institut Pasteur, 25-28 Rue du Docteur Roux, 75015 Paris, France.
Andrej Trauner
4Swiss Tropical and Public Health Institute, Basel, Switzerland.
5University of Basel, Basel, Switzerland.
Ilaria Piazza
6Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland.
Paola Picotti
6Institute of Biochemistry, Department of Biology, ETH Zürich, Zürich, Switzerland.
Sébastien Gagneux
4Swiss Tropical and Public Health Institute, Basel, Switzerland.
5University of Basel, Basel, Switzerland.
Sonia Borrell
4Swiss Tropical and Public Health Institute, Basel, Switzerland.
5University of Basel, Basel, Switzerland.
Brigitte Gicquel
3Mycobacterial Genetics Unit, Institut Pasteur, 25-28 Rue du Docteur Roux, 75015 Paris, France.
Joel Lelievre
7Disease of the Developing World, GlaxoSmithKline, Severo Ochoa, Tres Cantos, Madrid 28760, Spain.
Balazs Papp
2Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.
Uwe Sauer
1Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
