Research ArticleFUNGAL INFECTIONS
Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation
- View ORCID ProfileJoe L. Hsu1,2,
- View ORCID ProfileOlga V. Manouvakhova2,
- View ORCID ProfileKarl V. Clemons3,4,
- View ORCID ProfileMohammed Inayathullah5,
- View ORCID ProfileAllen B. Tu2,
- View ORCID ProfileRaymond A. Sobel6,7,
- View ORCID ProfileAmy Tian2,
- View ORCID ProfileHasan Nazik3,4,8,
- View ORCID ProfileVenkata R. Pothineni5,
- View ORCID ProfileShravani Pasupneti1,2,
- Xinguo Jiang2,
- View ORCID ProfileGundeep S. Dhillon1,
- View ORCID ProfileHarmeet Bedi1,
- Jayakumar Rajadas1,5,
- View ORCID ProfileHubertus Haas9,
- View ORCID ProfileLaure Aurelian10,
- David A. Stevens3,4 and
- View ORCID ProfileMark R. Nicolls1,2,*
- 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
- 3Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
- 4Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 5Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
- 6Veterans Affairs Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, CA 94304, USA.
- 7Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 8Department of Medical Microbiology, Istanbul University School of Medicine, Istanbul, Turkey.
- 9Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.
- 10Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- ↵*Corresponding author. Email: mnicolls{at}stanford.edu
See allHide authors and affiliations
Science Translational Medicine 21 Feb 2018:
Vol. 10, Issue 429, eaag2616
DOI: 10.1126/scitranslmed.aag2616
Vol. 10, Issue 429, eaag2616
DOI: 10.1126/scitranslmed.aag2616
Joe L. Hsu
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Olga V. Manouvakhova
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Karl V. Clemons
3Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
4Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mohammed Inayathullah
5Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Allen B. Tu
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Raymond A. Sobel
6Veterans Affairs Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, CA 94304, USA.
7Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amy Tian
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Hasan Nazik
3Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
4Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
8Department of Medical Microbiology, Istanbul University School of Medicine, Istanbul, Turkey.
Venkata R. Pothineni
5Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Shravani Pasupneti
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Xinguo Jiang
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Gundeep S. Dhillon
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Harmeet Bedi
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jayakumar Rajadas
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
5Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Hubertus Haas
9Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.
Laure Aurelian
10Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
David A. Stevens
3Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
4Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mark R. Nicolls
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
