Research ArticleFUNGAL INFECTIONS
Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation
- Joe L. Hsu1,2,
- Olga V. Manouvakhova2,
- Karl V. Clemons3,4,
- Mohammed Inayathullah5,
- Allen B. Tu2,
- Raymond A. Sobel6,7,
- Amy Tian2,
- Hasan Nazik3,4,8,
- Venkata R. Pothineni5,
- Shravani Pasupneti1,2,
- Xinguo Jiang2,
- Gundeep S. Dhillon1,
- Harmeet Bedi1,
- Jayakumar Rajadas1,5,
- Hubertus Haas9,
- Laure Aurelian10,
- David A. Stevens3,4 and
- Mark R. Nicolls1,2,*
- 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 2Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
- 3Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.
- 4Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 5Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
- 6Veterans Affairs Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, CA 94304, USA.
- 7Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- 8Department of Medical Microbiology, Istanbul University School of Medicine, Istanbul, Turkey.
- 9Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.
- 10Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
- ↵*Corresponding author. Email: mnicolls{at}stanford.edu
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Science Translational Medicine 21 Feb 2018:
Vol. 10, Issue 429, eaag2616
DOI: 10.1126/scitranslmed.aag2616
Vol. 10, Issue 429, eaag2616
DOI: 10.1126/scitranslmed.aag2616
Joe L. Hsu
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Olga V. Manouvakhova
Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Karl V. Clemons
Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mohammed Inayathullah
Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Allen B. Tu
Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Raymond A. Sobel
Veterans Affairs Palo Alto Health Care System, Pathology and Laboratory Service, Palo Alto, CA 94304, USA.Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amy Tian
Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Hasan Nazik
Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Department of Medical Microbiology, Istanbul University School of Medicine, Istanbul, Turkey.
Venkata R. Pothineni
Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Shravani Pasupneti
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Xinguo Jiang
Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
Gundeep S. Dhillon
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Harmeet Bedi
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jayakumar Rajadas
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94304, USA.
Hubertus Haas
Division of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria.
Laure Aurelian
Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
David A. Stevens
Infectious Diseases Research Laboratory, California Institute for Medical Research, San Jose, CA 95128, USA.Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mark R. Nicolls
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.Veterans Affairs Palo Alto Health Care System, Medical Service, Palo Alto, CA 94304, USA.
