Contents
21 February 2018
Vol 10, Issue 429
Vol 10, Issue 429
Research Articles
- Eosinophil depletion suppresses radiation-induced small intestinal fibrosis
Eosinophils are a potential target for treating radiation-induced intestinal fibrosis.
- In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy
A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity.
- High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds
The mode of action of new antimicrobial compounds can be predicted from changes in metabolome profiles in Mycobacterium.
- Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
Oncogenic JAK mutation sensitizes myeloproliferative neoplasms to immune checkpoint inhibition.
- Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation
Increased ferric iron in allografts triggers a switch in the growth of the mold Aspergillus fumigatus from a colonizing to an invasive phenotype.
Editors' Choice
- Finding a broken heart
A noninvasive imaging method identifies acute heart transplant rejection.
- A QuIC possibility for the diagnosis of Parkinson’s disease
α-Synuclein seeding activity can be measured quickly and might prove useful for the diagnosis of α-synucleinopathies.
- A new hope for KRAS mutant cancers
c-RAF ablation in KRAS mutant lung tumors is highly efficacious, supporting the development of selective c-RAF inhibitors for clinical use.
About The Cover
ONLINE COVER Eosinophil Instigation of Intestinal Fibrosis. Radiation treatment for cancer can unfortunately lead to intestinal fibrosis. Through examination of patient biopsies and a mouse radiation model, Takemura et al. observed that eosinophils were crucial for this process, whereas lymphocytes were dispensable. Shown here is an eosinophil interacting with a stromal cell in the intestine following radiation. Depletion of eosinophils prevented fibrosis, and as eosinophil-targeting antibodies are already in the clinic, relief for radiation patients might not be faraway. [CREDIT: TAKEMURA ET AL./SCIENCE TRANSLATIONAL MEDICINE]
