21 February 2018
Vol 10, Issue 429

About The Cover

Cover image expansion

ONLINE COVER Eosinophil Instigation of Intestinal Fibrosis. Radiation treatment for cancer can unfortunately lead to intestinal fibrosis. Through examination of patient biopsies and a mouse radiation model, Takemura et al. observed that eosinophils were crucial for this process, whereas lymphocytes were dispensable. Shown here is an eosinophil interacting with a stromal cell in the intestine following radiation. Depletion of eosinophils prevented fibrosis, and as eosinophil-targeting antibodies are already in the clinic, relief for radiation patients might not be faraway. [CREDIT: TAKEMURA ET AL./SCIENCE TRANSLATIONAL MEDICINE]