Research ArticleInfluenza

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

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Science Translational Medicine  14 Feb 2018:
Vol. 10, Issue 428, eaan8405
DOI: 10.1126/scitranslmed.aan8405

Article Information

vol. 10 no. 428

Print ISSN: 
Online ISSN: 
  • Received for publication May 26, 2017
  • Resubmitted September 5, 2017
  • Accepted for publication December 22, 2017
  • .

Author Information

  1. Marios Koutsakos1,
  2. Adam K. Wheatley1,
  3. Liyen Loh1,
  4. E. Bridie Clemens1,
  5. Sneha Sant1,
  6. Simone Nüssing1,
  7. Annette Fox1,
  8. Amy W. Chung1,
  9. Karen L. Laurie2,
  10. Aeron C. Hurt2,
  11. Steve Rockman1,3,
  12. Martha Lappas4,
  13. Thomas Loudovaris5,
  14. Stuart I. Mannering5,
  15. Glen P. Westall6,
  16. Michael Elliot7,8,
  17. Stuart G. Tangye9,10,
  18. Linda M. Wakim1,
  19. Stephen J. Kent1,11,12,
  20. Thi H. O. Nguyen1,*, and
  21. Katherine Kedzierska1,*,
  1. 1Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria 3010, Australia.
  2. 2World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
  3. 3Seqirus, 63 Poplar Road, Parkville, Victoria 3052, Australia.
  4. 4Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria 3084, Australia.
  5. 5Immunology and Diabetes Unit, St Vincent’s Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
  6. 6Lung Transplant Unit, Alfred Hospital, Melbourne, Victoria 3004, Australia.
  7. 7Sydney Medical School, University of Sydney, Sydney, New South Wales 2006, Australia.
  8. 8Chris O’Brien Lifehouse Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
  9. 9Immunology Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  10. 10St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.
  11. 11Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia.
  12. 12ARC Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria 3010, Australia.
  1. Corresponding author. Email: kkedz{at} (K.K.); tho.nguyen{at} (T.H.O.N.)
    • * These authors contributed equally to this work.


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