Research ArticleInfluenza

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

See allHide authors and affiliations

Science Translational Medicine  14 Feb 2018:
Vol. 10, Issue 428, eaan8405
DOI: 10.1126/scitranslmed.aan8405

Investigating influenza immunity

Seasonal influenza vaccines have been recommended for decades, but studies focused on antigen-specific lymphocytes in humans are sparse. Koutsakos et al. examined longitudinal samples of influenza-vaccinated individuals to determine what responses generate protective immunity. Vaccination could induce circulating T follicular helper memory cells, antibody-secreting cells, and memory B cells, but did not seem to affect other types of lymphocytes. Existing anti-influenza antibodies at the time of vaccination dampened these responses. They probed different types of human tissues to hunt for influenza memory B cells, thereby showing that the memory response exists outside the circulation. Better targeting these cells could improve influenza vaccine efficacy.

View Full Text

Stay Connected to Science Translational Medicine