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Research ArticleCancer
Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence
- View ORCID ProfileGiovanna Cutrona1,*,†,
- View ORCID ProfileClaudio Tripodo2,*,
- Serena Matis1,
- Anna Grazia Recchia3,4,
- Carlotta Massucco1,
- Marina Fabbi5,
- Monica Colombo1,
- Laura Emionite6,
- Sabina Sangaletti7,
- View ORCID ProfileAlessandro Gulino2,
- Daniele Reverberi1,
- Rosanna Massara1,
- Simona Boccardo8,
- Daniela de Totero1,
- Sandra Salvi8,
- Michele Cilli6,
- View ORCID ProfileMariavaleria Pellicanò3,4,
- View ORCID ProfileMartina Manzoni9,10,
- Sonia Fabris10,
- Irma Airoldi11,
- Francesca Valdora1,12,
- View ORCID ProfileSilvano Ferrini5,
- Massimo Gentile3,4,
- Ernesto Vigna3,4,
- Sabrina Bossio4,
- Laura De Stefano4,
- Angela Palummo4,
- Giovanni Iaquinta4,
- Martina Cardillo12,
- Simonetta Zupo13,
- Giannamaria Cerruti13,
- Adalberto Ibatici14,
- View ORCID ProfileAntonino Neri9,10,
- View ORCID ProfileFranco Fais1,12,
- Manlio Ferrarini15 and
- Fortunato Morabito3,4
- 1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
- 2Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, 90127 Palermo, Italy.
- 3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
- 4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
- 5Biotherapy Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- 6Animal Facility, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- 7Molecular Immunology Unit, IRCCS Istituto Nazionale Tumori, 20134 Milan, Italy.
- 8Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- 9Department of Oncology and Hemato-Oncology, University of Milano, 20122 Milan, Italy.
- 10Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
- 11Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
- 12Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
- 13Molecular Diagnostic Unit, Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- 14Hematology and Bone Marrow Transplantation Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- 15Scientific Direction, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
- ↵†Corresponding author. Email: giovanna.cutrona{at}hsanmartino.it
↵* These authors contributed equally to this work.
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Science Translational Medicine 14 Feb 2018:
Vol. 10, Issue 428, eaal1571
DOI: 10.1126/scitranslmed.aal1571
Vol. 10, Issue 428, eaal1571
DOI: 10.1126/scitranslmed.aal1571
Giovanna Cutrona
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Claudio Tripodo
2Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, 90127 Palermo, Italy.
Serena Matis
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Anna Grazia Recchia
3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Carlotta Massucco
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Marina Fabbi
5Biotherapy Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Monica Colombo
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Laura Emionite
6Animal Facility, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Sabina Sangaletti
7Molecular Immunology Unit, IRCCS Istituto Nazionale Tumori, 20134 Milan, Italy.
Alessandro Gulino
2Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, 90127 Palermo, Italy.
Daniele Reverberi
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Rosanna Massara
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Simona Boccardo
8Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Daniela de Totero
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
Sandra Salvi
8Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Michele Cilli
6Animal Facility, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Mariavaleria Pellicanò
3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Martina Manzoni
9Department of Oncology and Hemato-Oncology, University of Milano, 20122 Milan, Italy.
10Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Sonia Fabris
10Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Irma Airoldi
11Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Francesca Valdora
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
12Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Silvano Ferrini
5Biotherapy Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Massimo Gentile
3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Ernesto Vigna
3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Sabrina Bossio
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Laura De Stefano
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Angela Palummo
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Giovanni Iaquinta
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
Martina Cardillo
12Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Simonetta Zupo
13Molecular Diagnostic Unit, Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Giannamaria Cerruti
13Molecular Diagnostic Unit, Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Adalberto Ibatici
14Hematology and Bone Marrow Transplantation Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Antonino Neri
9Department of Oncology and Hemato-Oncology, University of Milano, 20122 Milan, Italy.
10Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Franco Fais
1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
12Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Manlio Ferrarini
15Scientific Direction, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
Fortunato Morabito
3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
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