Research ArticleCancer

Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence

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Science Translational Medicine  14 Feb 2018:
Vol. 10, Issue 428, eaal1571
DOI: 10.1126/scitranslmed.aal1571

Article Information

vol. 10 no. 428

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History: 
  • Received for publication October 6, 2016
  • Resubmitted June 28, 2017
  • Accepted for publication November 15, 2017
  • .

Author Information

  1. Giovanna Cutrona1,*,,
  2. Claudio Tripodo2,*,
  3. Serena Matis1,
  4. Anna Grazia Recchia3,4,
  5. Carlotta Massucco1,
  6. Marina Fabbi5,
  7. Monica Colombo1,
  8. Laura Emionite6,
  9. Sabina Sangaletti7,
  10. Alessandro Gulino2,
  11. Daniele Reverberi1,
  12. Rosanna Massara1,
  13. Simona Boccardo8,
  14. Daniela de Totero1,
  15. Sandra Salvi8,
  16. Michele Cilli6,
  17. Mariavaleria Pellicanò3,4,
  18. Martina Manzoni9,10,
  19. Sonia Fabris10,
  20. Irma Airoldi11,
  21. Francesca Valdora1,12,
  22. Silvano Ferrini5,
  23. Massimo Gentile3,4,
  24. Ernesto Vigna3,4,
  25. Sabrina Bossio4,
  26. Laura De Stefano4,
  27. Angela Palummo4,
  28. Giovanni Iaquinta4,
  29. Martina Cardillo12,
  30. Simonetta Zupo13,
  31. Giannamaria Cerruti13,
  32. Adalberto Ibatici14,
  33. Antonino Neri9,10,
  34. Franco Fais1,12,
  35. Manlio Ferrarini15 and
  36. Fortunato Morabito3,4
  1. 1Molecular Pathology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliera Universitaria (AOU) San Martino–Istituto Nazionale per la Ricerca sul Cancro (IST), 16132 Genoa, Italy.
  2. 2Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, 90127 Palermo, Italy.
  3. 3Hematology Unit, Department of Onco-Hematology, Azienda Ospedaliera (AO) of Cosenza, 87100 Cosenza, Italy.
  4. 4Biotechnology Research Unit, Aprigliano, AO/Azienda Sanitaria Provinciale (ASP) of Cosenza, 87051 Cosenza, Italy.
  5. 5Biotherapy Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  6. 6Animal Facility, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  7. 7Molecular Immunology Unit, IRCCS Istituto Nazionale Tumori, 20134 Milan, Italy.
  8. 8Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  9. 9Department of Oncology and Hemato-Oncology, University of Milano, 20122 Milan, Italy.
  10. 10Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  11. 11Stem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
  12. 12Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
  13. 13Molecular Diagnostic Unit, Division of Histopathology and Cytopathology, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  14. 14Hematology and Bone Marrow Transplantation Unit, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  15. 15Scientific Direction, IRCCS AOU San Martino–IST, 16132 Genoa, Italy.
  1. Corresponding author. Email: giovanna.cutrona{at}hsanmartino.it
    • * These authors contributed equally to this work.

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