14 February 2018
Vol 10, Issue 428

About The Cover

Cover image expansion

ONLINE COVER Fighting Flu. Pictured here is a vaccine vial. Seasonal influenza vaccines typically raise narrow immune responses. Koutsakos et al. carefully probed the immune response in vaccinated individuals over several years to determine which immune components were associated with strong responses. Pre-existing antibodies hampered vaccine responses, which were dependent on circulating T follicular helper cells and different types of memory B cells. The investigators also detected influenza-specific memory cells in human tissues. These results could help to guide the development of more effective influenza vaccines. [CREDIT: ISTOCKPHOTO.COM/THEYOK]