Contents
14 February 2018
Vol 10, Issue 428
Vol 10, Issue 428
Research Articles
- Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity
Analysis of influenza-specific B cells during antigen exposure and tissue compartmentalization provides insights into human B cell memory.
- FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
FoxO play a key role in postnatal cartilage development, maturation, homeostasis, and osteoarthritis pathogenesis.
- Microenvironmental regulation of the IL-23R/IL-23 axis overrides chronic lymphocytic leukemia indolence
An autocrine/paracrine loop involving IL-23 and the IL-23R complex drives CLL cell expansion and represents a potential therapeutic target.
- An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye
A kinase inhibitor shows promise as a topical antiviral against ocular herpes.
- Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Selective irreversible inhibitors of selenoprotein TXNRD1 yield anticancer efficacy without overt systemic toxicity in mouse models.
Editors' Choice
- Stressed out? Making new, but different, neurons
Neurons born when coping with stress respond differently to subsequent stress.
- How to train your microbiome to eat broccoli
Engineered commensal bacteria produce colorectal cancer–fighting compounds from ingested broccoli.
- Stressing Myc-driven cancer out
Myc-driven cancers can be targeted with the IRE1α inhibitor.
About The Cover
ONLINE COVER Fighting Flu. Pictured here is a vaccine vial. Seasonal influenza vaccines typically raise narrow immune responses. Koutsakos et al. carefully probed the immune response in vaccinated individuals over several years to determine which immune components were associated with strong responses. Pre-existing antibodies hampered vaccine responses, which were dependent on circulating T follicular helper cells and different types of memory B cells. The investigators also detected influenza-specific memory cells in human tissues. These results could help to guide the development of more effective influenza vaccines. [CREDIT: ISTOCKPHOTO.COM/THEYOK]