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Research ArticleCancer
Targeting p53-dependent stem cell loss for intestinal chemoprotection
- View ORCID ProfileBrian J. Leibowitz1,2,
- View ORCID ProfileLiheng Yang2,3,
- View ORCID ProfileLiang Wei1,2,
- View ORCID ProfileMonica E. Buchanan2,3,
- Madani Rachid2,
- View ORCID ProfileRobert A. Parise2,
- View ORCID ProfileJan H. Beumer2,3,4,5,
- Julie L. Eiseman2,3,5,
- View ORCID ProfileRobert E. Schoen2,4,
- Lin Zhang2,3 and
- View ORCID ProfileJian Yu1,2,*
- 1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
- 3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 4Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
- 5Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.
- ↵*Corresponding author. Email: yuj2{at}upmc.edu
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Science Translational Medicine 07 Feb 2018:
Vol. 10, Issue 427, eaam7610
DOI: 10.1126/scitranslmed.aam7610
Vol. 10, Issue 427, eaam7610
DOI: 10.1126/scitranslmed.aam7610
Brian J. Leibowitz
1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Liheng Yang
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Liang Wei
1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Monica E. Buchanan
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Madani Rachid
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Robert A. Parise
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Jan H. Beumer
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
4Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
5Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.
Julie L. Eiseman
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
5Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.
Robert E. Schoen
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
4Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Lin Zhang
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
3Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Jian Yu
1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
2UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
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