07 February 2018
Vol 10, Issue 427

About The Cover

Cover image expansion

ONLINE COVER Countering Constriction in Asthma. Asthma patients can be refractory to current therapies, so alternative approaches are needed. Yin et al. demonstrated that TSG12, a transgelin-2 agonist, relaxed airways in preclinical asthma mouse models. Shown here is the reduced traction force of human airway smooth muscle cells after treatment with TSG12 (second and fourth images), compared to untreated control cells (first and third images). This agonist was more potent than currently used β2-agonists and could help patients with asthma breathe more easily. [CREDIT: YIN ET AL./SCIENCE TRANSLATIONAL MEDICINE]