Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

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Science Translational Medicine  31 Jan 2018:
Vol. 10, Issue 426, eaan5174
DOI: 10.1126/scitranslmed.aan5174


Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.

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