31 January 2018
Vol 10, Issue 426

About The Cover

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ONLINE COVER All in the Flavivirus Family. The Zika virus epidemic in Latin America was unexpected and devastating, and now scientists are concerned that other flavivirus family members may be able to cause severe birth defects or miscarriage. Platt and colleagues infected immunocompetent pregnant mice and human placental explants with different types of flaviviruses. Shown here is West Nile virus (green) infecting fetal membrane cells from a human placental explant. The investigators discovered that other flaviviruses were capable of infecting the placenta and causing fetal damage in these model systems. These results indicate that future epidemics of Zika-related viruses may have similar effects. [CREDIT: PLATT ET AL./SCIENCE TRANSLATIONAL MEDICINE]