Contents
31 January 2018
Vol 10, Issue 426
Vol 10, Issue 426
Research Articles
- Zika virus–related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice
West Nile and Powassan viruses cause fetal demise in mice and replicate in human placental tissue.
- Eradication of spontaneous malignancy by local immunotherapy
In situ vaccination with low doses of TLR ligands and anti-OX40 antibodies can cure widespread cancers in preclinical models.
- Sensory deprivation after focal ischemia in mice accelerates brain remapping and improves functional recovery through Arc-dependent synaptic plasticity
Sensory loss induced by whisker trimming facilitates behavioral recovery after focal cerebral ischemia in mice by accelerating Arc-dependent neuronal remapping into the whisker barrel cortex.
Report
- Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma
The antibiotic tigecycline and the BCL2 inhibitor venetoclax cooperate to treat MYC/BCL2 double-hit lymphomas in xenografted mice.
Review
- Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies
Recent insights into the tissue-specific origin of myofibroblasts are paving the way for new organ-specific antifibrotic therapies.
Editors' Choice
- The case for tau
Pathology consistent with chronic traumatic encephalopathy was found in postmortem brains of teenagers after concussion and was reproduced in a mouse model of traumatic brain injury.
- Time’s up for tumors
Small molecules targeting the circadian clock can wage metabolic war on cancer cells.
- p53: Jack of all (cell death) trades, master of all
p53 has well-established roles in modulating many forms of cell death including apoptosis, autophagy, necrosis, necroptosis, and increasingly, ferroptosis as well.
- The way to a heart is through the stomach
Ghrelin maintains coronary artery perfusion following acute myocardial infarction.
About The Cover
ONLINE COVER All in the Flavivirus Family. The Zika virus epidemic in Latin America was unexpected and devastating, and now scientists are concerned that other flavivirus family members may be able to cause severe birth defects or miscarriage. Platt and colleagues infected immunocompetent pregnant mice and human placental explants with different types of flaviviruses. Shown here is West Nile virus (green) infecting fetal membrane cells from a human placental explant. The investigators discovered that other flaviviruses were capable of infecting the placenta and causing fetal damage in these model systems. These results indicate that future epidemics of Zika-related viruses may have similar effects. [CREDIT: PLATT ET AL./SCIENCE TRANSLATIONAL MEDICINE]