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Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues

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Science Translational Medicine  24 Jan 2018:
Vol. 10, Issue 425, eaar2041
DOI: 10.1126/scitranslmed.aar2041

Article Information

vol. 10 no. 425

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History: 
  • Received for publication September 3, 2016
  • Resubmitted October 15, 2017
  • Accepted for publication November 8, 2017
  • .

Author Information

  1. Aadil A. Khan1,2,
  2. James T. Paget1,2,
  3. Martin McLaughlin1,
  4. Joan N. Kyula1,
  5. Michelle J. Wilkinson1,
  6. Timothy Pencavel1,
  7. David Mansfield1,
  8. Victoria Roulstone1,
  9. Rohit Seth1,
  10. Martin Halle3,4,
  11. Navita Somaiah1,
  12. Jessica K. R. Boult5,
  13. Simon P. Robinson5,
  14. Hardev S. Pandha6,
  15. Richard G. Vile7,
  16. Alan A. Melcher8,
  17. Paul A. Harris2 and
  18. Kevin J. Harrington1,*
  1. 1Targeted Therapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SW3 6JB, UK.
  2. 2Department of Plastic Surgery, The Royal Marsden Hospital, London SW3 6JJ, UK.
  3. 3Department of Molecular Medicine and Surgery, Section of Plastic Surgery, Karolinska Institute, Stockholm 17176, Sweden.
  4. 4Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm 17176, Sweden.
  5. 5Magnetic Resonance Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK.
  6. 6Postgraduate Medical School, University of Surrey, Guildford GU2 7XH, UK.
  7. 7Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA.
  8. 8Translational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW3 6JB, UK.
  1. *Corresponding author. Email: kevin.harrington{at}icr.ac.uk

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