Research ArticleCancer

Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition

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Science Translational Medicine  24 Jan 2018:
Vol. 10, Issue 425, eaao1613
DOI: 10.1126/scitranslmed.aao1613

A virus’s little helper

Oncolytic viruses, which kill cancer cells, can offer an effective and versatile approach for treating cancer. However, they need to reach tumor cells and get inside them to achieve a therapeutic effect, and this does not always happen. Selman et al. identified a promising solution for this problem by combining oncolytic vesicular stomatitis virus with dimethyl fumarate, a small-molecule drug that is already in use for some nonmalignant disorders and may also have direct anticancer effects. Dimethyl fumarate promoted viral infection of cancer cells, and the combined treatment was effective in multiple cancer models, including those that did not respond to virus or drug treatment alone.

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