Miniaturized neural system for chronic, local intracerebral drug delivery

Canan Dagdeviren; Khalil B. Ramadi; Pauline Joe; Kevin Spencer; Helen N. Schwerdt; Hideki Shimazu; Sebastien Delcasso; Ken-ichi Amemori; Carlos Nunez-Lopez; Ann M. Graybiel; Michael J. Cima; Robert Langer

doi:10.1126/scitranslmed.aan2742

Research ArticleDrug Delivery

Miniaturized neural system for chronic, local intracerebral drug delivery

View ORCID ProfileCanan Dagdeviren¹,²,
View ORCID ProfileKhalil B. Ramadi¹,³,
View ORCID ProfilePauline Joe¹,
Kevin Spencer¹,
Helen N. Schwerdt¹,⁴,
View ORCID ProfileHideki Shimazu⁴,
View ORCID ProfileSebastien Delcasso⁴,
Ken-ichi Amemori⁴,
View ORCID ProfileCarlos Nunez-Lopez¹,⁵,
View ORCID ProfileAnn M. Graybiel⁴,
View ORCID ProfileMichael J. Cima¹,⁶,* and
View ORCID ProfileRobert Langer¹,³,*

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁴McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain.
⁶Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

↵*Corresponding author. Email: mjcima{at}mit.edu (M.J.C.); rlanger{at}mit.edu (R.L.)

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Science Translational Medicine 24 Jan 2018:
Vol. 10, Issue 425, eaan2742
DOI: 10.1126/scitranslmed.aan2742

Canan Dagdeviren

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Khalil B. Ramadi

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Pauline Joe

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Kevin Spencer

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Helen N. Schwerdt

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Hideki Shimazu

4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Sebastien Delcasso

4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Ken-ichi Amemori

4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Carlos Nunez-Lopez

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain.

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Ann M. Graybiel

4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Michael J. Cima

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: mjcima@mit.edu rlanger@mit.edu

Robert Langer

1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: mjcima@mit.edu rlanger@mit.edu

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An implantable, remotely controllable, miniaturized drug delivery system permits dynamic adjustment of therapy with a pinpoint spatial accuracy in the brain.

Miniaturized neural system for chronic, local intracerebral drug delivery

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