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Research ArticleDrug Delivery
Miniaturized neural system for chronic, local intracerebral drug delivery
- View ORCID ProfileCanan Dagdeviren1,2,
- View ORCID ProfileKhalil B. Ramadi1,3,
- View ORCID ProfilePauline Joe1,
- Kevin Spencer1,
- Helen N. Schwerdt1,4,
- View ORCID ProfileHideki Shimazu4,
- View ORCID ProfileSebastien Delcasso4,
- Ken-ichi Amemori4,
- View ORCID ProfileCarlos Nunez-Lopez1,5,
- View ORCID ProfileAnn M. Graybiel4,
- View ORCID ProfileMichael J. Cima1,6,* and
- View ORCID ProfileRobert Langer1,3,*
- 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 2Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 5IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain.
- 6Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- ↵*Corresponding author. Email: mjcima{at}mit.edu (M.J.C.); rlanger{at}mit.edu (R.L.)
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Science Translational Medicine 24 Jan 2018:
Vol. 10, Issue 425, eaan2742
DOI: 10.1126/scitranslmed.aan2742
Vol. 10, Issue 425, eaan2742
DOI: 10.1126/scitranslmed.aan2742
Canan Dagdeviren
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Khalil B. Ramadi
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Pauline Joe
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kevin Spencer
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Helen N. Schwerdt
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hideki Shimazu
4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sebastien Delcasso
4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ken-ichi Amemori
4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Carlos Nunez-Lopez
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
5IQS School of Engineering, Ramon Llull University, 08017 Barcelona, Spain.
Ann M. Graybiel
4McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Michael J. Cima
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
6Department of Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Robert Langer
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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