Research ArticleHIV

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes

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Science Translational Medicine  24 Jan 2018:
Vol. 10, Issue 425, eaam6354
DOI: 10.1126/scitranslmed.aam6354

Article Information

vol. 10 no. 425

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 27, 2016
  • Resubmitted August 29, 2017
  • Accepted for publication December 1, 2017
  • .

Author Information

  1. Aida Sivro1,2,
  2. Alexandra Schuetz3,4,5,
  3. Daniel Sheward6,
  4. Vineet Joag7,
  5. Sergey Yegorov7,
  6. Lenine J. Liebenberg1,
  7. Nonhlanhla Yende-Zuma1,
  8. Andrew Stalker2,
  9. Ruth S. Mwatelah2,
  10. Philippe Selhorst6,
  11. Nigel Garrett1,
  12. Natasha Samsunder1,
  13. Anisha Balgobin1,
  14. Fatima Nawaz8,
  15. Claudia Cicala8,
  16. James Arthos8,
  17. Anthony S. Fauci8,
  18. Aggrey Omu Anzala9,10,
  19. Joshua Kimani2,10,
  20. Bernard S. Bagaya11,12,
  21. Noah Kiwanuka11,13,
  22. Carolyn Williamson1,6,
  23. Rupert Kaul7,14,15,
  24. Jo-Ann S. Passmore1,6,16,
  25. Nittaya Phanuphak17,
  26. Jintanat Ananworanich4,17,18,
  27. Aftab Ansari19,
  28. Quarraisha Abdool Karim1,20,
  29. Salim S. Abdool Karim1,20,
  30. Lyle R. McKinnon1,2,10,*,
  31. on behalf of the CAPRISA004 and RV254 study groups
  1. 1Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban 4013, South Africa.
  2. 2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada.
  3. 3Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  4. 4U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute, Silver Spring, MD 20817, USA.
  5. 5Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  6. 6Division of Medical Virology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service, Cape Town 7925, South Africa.
  7. 7Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  8. 8Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892–9806, USA.
  9. 9Kenyan AIDS Vaccine Initiative, Nairobi 00202, Kenya.
  10. 10Department of Medical Microbiology, University of Nairobi, Nairobi 00202, Kenya.
  11. 11Uganda Virus Research Institute–International AIDS Vaccine Initiative HIV Vaccine Program, Plot 51-59, Nakiwogo Road, Entebbe, Uganda.
  12. 12Department of Epidemiology and Biostatistics, Makerere University, P.O. Box 7062, Kampala, Uganda.
  13. 13Department of Immunology and Molecular Biology, Makerere University, P.O. Box 7062, Kampala, Uganda.
  14. 14Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  15. 15University Health Network, Toronto, Ontario M5G IL7, Canada.
  16. 16National Health Laboratory Services, Cape Town 8005, South Africa.
  17. 17South East Asia Research Collaboration in HIV (SEARCH), The Thai Red Cross AIDS Research Centre, Bangkok 10330, Thailand.
  18. 18University of Amsterdam, 1000 GG Amsterdam, Netherlands.
  19. 19Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
  20. 20Department of Epidemiology, Columbia University, New York, NY 10032, USA.
  1. *Corresponding author. Email: lyle.mckinnon@umanitoba.ca

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