24 January 2018
Vol 10, Issue 425

About The Cover

Cover image expansion

ONLINE COVER Drug and Virus Team Up to Treat Cancer. This image shows a viral plaque made by an oncolytic virus infecting cancer cells. Although oncolytic viruses can be quite effective at killing cancer cells, they do not work for all patients or all tumor types. To improve the effectiveness of oncolytic vesicular stomatitis virus, Selman et al. combined it with dimethyl fumarate, a clinically approved drug, and showed that this drug promotes viral infection of cancer cells. The combination of dimethyl fumarate and oncolytic virus worked better than the drug or virus alone and was effective in multiple cancer types. [CREDIT: MOHAMMED SELMAN/UNIVERSITY OF OTTAWA]