Contents
24 January 2018
Vol 10, Issue 425
Vol 10, Issue 425
Research Articles
- Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition
Dimethyl fumarate combined with oncolytic virus increases its potency in cancer treatment.
- Miniaturized neural system for chronic, local intracerebral drug delivery
An implantable, remotely controllable, miniaturized drug delivery system permits dynamic adjustment of therapy with a pinpoint spatial accuracy in the brain.
- Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Vascular protection using gene therapy can reduce the late toxicities of radiotherapy.
- Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes
CD4+ T cells expressing α4β7 play an important role in HIV pathogenesis.
Editors' Choice
- Joining the resistance
The effect of antibiotic resistance genes on the gut microbiome is examined in preterm infants before and after antibiotic administration.
- Neuronal suppression causing depression?
Suppressed dopaminergic activity in a specific brain area may play a causal role in depression.
- Maestro macrophages conduct a widely disseminated symphony
Macrophages break down tissue junctions and allow for breast cancer dissemination and metastasis.
- Oh, the places you’ll go!
An in vivo selection strategy identifies an antibody that induces stem cells to differentiate into microglia-like cells, migrate to the brain, and reduce β−amyloid plaques in mice.
Erratum
About The Cover
ONLINE COVER Drug and Virus Team Up to Treat Cancer. This image shows a viral plaque made by an oncolytic virus infecting cancer cells. Although oncolytic viruses can be quite effective at killing cancer cells, they do not work for all patients or all tumor types. To improve the effectiveness of oncolytic vesicular stomatitis virus, Selman et al. combined it with dimethyl fumarate, a clinically approved drug, and showed that this drug promotes viral infection of cancer cells. The combination of dimethyl fumarate and oncolytic virus worked better than the drug or virus alone and was effective in multiple cancer types. [CREDIT: MOHAMMED SELMAN/UNIVERSITY OF OTTAWA]
