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Research ArticleCancer
Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
- View ORCID ProfileYan Lan*,
- View ORCID ProfileDong Zhang,
- View ORCID ProfileChunxiao Xu,
- View ORCID ProfileKenneth W. Hance†,
- View ORCID ProfileBo Marelli,
- View ORCID ProfileJin Qi,
- View ORCID ProfileHuakui Yu,
- View ORCID ProfileGuozhong Qin,
- View ORCID ProfileAroop Sircar,
- Vivian M. Hernández,
- Molly H. Jenkins,
- Rachel E. Fontana,
- Amit Deshpande,
- View ORCID ProfileGeorge Locke,
- Helen Sabzevari‡,
- Laszlo Radvanyi and
- View ORCID ProfileKin-Ming Lo*
- ↵*Corresponding author. Email: yan.lan{at}emdserono.com (Y.L.); kinming.lo{at}emdserono.com (K.-M.L.)
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Science Translational Medicine 17 Jan 2018:
Vol. 10, Issue 424, eaan5488
DOI: 10.1126/scitranslmed.aan5488
Vol. 10, Issue 424, eaan5488
DOI: 10.1126/scitranslmed.aan5488
Yan Lan
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Dong Zhang
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Chunxiao Xu
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Kenneth W. Hance
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Bo Marelli
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Jin Qi
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Huakui Yu
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Guozhong Qin
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Aroop Sircar
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Vivian M. Hernández
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Molly H. Jenkins
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Rachel E. Fontana
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Amit Deshpande
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
George Locke
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Helen Sabzevari
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Laszlo Radvanyi
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
Kin-Ming Lo
EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
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