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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

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Science Translational Medicine  17 Jan 2018:
Vol. 10, Issue 424, eaan5488
DOI: 10.1126/scitranslmed.aan5488

Article Information

vol. 10 no. 424

DOI: 
https://doi.org/10.1126/scitranslmed.aan5488
PubMed: 
29343622
Published By: 
American Association for the Advancement of Science
Print ISSN: 
1946-6234
Online ISSN: 
1946-6242
History: 
  • Received for publication May 2, 2017
  • Resubmitted October 4, 2017
  • Accepted for publication November 13, 2017
  • .
Copyright & Usage: 
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

Author Information

  1. Yan Lan*,
  2. Dong Zhang,
  3. Chunxiao Xu,
  4. Kenneth W. Hance†,
  5. Bo Marelli,
  6. Jin Qi,
  7. Huakui Yu,
  8. Guozhong Qin,
  9. Aroop Sircar,
  10. Vivian M. Hernández,
  11. Molly H. Jenkins,
  12. Rachel E. Fontana,
  13. Amit Deshpande,
  14. George Locke,
  15. Helen Sabzevari‡,
  16. Laszlo Radvanyi and
  17. Kin-Ming Lo*
  1. EMD Serono Research and Development Institute Inc., Billerica, MA 01821, USA.
  1. ↵*Corresponding author. Email: yan.lan{at}emdserono.com (Y.L.); kinming.lo{at}emdserono.com (K.-M.L.)

  • ↵† Present address: GlaxoSmithKline, Collegeville, PA 19426, USA.

  • ↵‡ Present address: Intrexon Corporation, Germantown, MD 20876, USA.

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Jan 201873735171228
Feb 20181280155351
Mar 20181216189410
Apr 201876993241
May 20181292136312
Jun 2018935146207
Jul 201860299146
Aug 2018440202160
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Oct 2018429165165
Nov 2018519163153
Dec 2018380110108
Jan 2019185270259
Feb 201961772774
Mar 201938452520
Apr 201919381400
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Aug 201954326384
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Dec 201942313290
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