Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

Dennis Jones; Eelco F. J. Meijer; Cedric Blatter; Shan Liao; Ethel R. Pereira; Echoe M. Bouta; Keehoon Jung; Shan Min Chin; Peigen Huang; Lance L. Munn; Benjamin J. Vakoc; Michael Otto; Timothy P. Padera

doi:10.1126/scitranslmed.aam7964

Research ArticleVascular Biology

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

View ORCID ProfileDennis Jones¹,²,
View ORCID ProfileEelco F. J. Meijer¹,²,
Cedric Blatter²,³,
Shan Liao¹,*,
View ORCID ProfileEthel R. Pereira¹,²,
View ORCID ProfileEchoe M. Bouta¹,²,
Keehoon Jung¹,²,
View ORCID ProfileShan Min Chin¹,²,
View ORCID ProfilePeigen Huang¹,²,
View ORCID ProfileLance L. Munn¹,²,
Benjamin J. Vakoc²,³,
View ORCID ProfileMichael Otto⁴ and
View ORCID ProfileTimothy P. Padera¹,²,†

¹Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.
²Harvard Medical School, Boston, MA 02115, USA.
³Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
⁴Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

↵†Corresponding author. Email: tpadera{at}steele.mgh.harvard.edu

↵* Present address: Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada.

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Science Translational Medicine 17 Jan 2018:
Vol. 10, Issue 424, eaam7964
DOI: 10.1126/scitranslmed.aam7964

Dennis Jones

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Dennis Jones

Eelco F. J. Meijer

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Cedric Blatter

2Harvard Medical School, Boston, MA 02115, USA.

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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Shan Liao

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

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Ethel R. Pereira

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Echoe M. Bouta

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Keehoon Jung

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Shan Min Chin

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Peigen Huang

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Lance L. Munn

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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Benjamin J. Vakoc

2Harvard Medical School, Boston, MA 02115, USA.

3Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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Michael Otto

4Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

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Timothy P. Padera

1Edwin L. Steele Laboratory, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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For correspondence: tpadera@steele.mgh.harvard.edu

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Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

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