17 January 2018
Vol 10, Issue 424

About The Cover

Cover image expansion

ONLINE COVER Nebulized Nanoparticles for Heart Therapy. Here we see an illustration of inhaled nanoparticles (green) reaching the heart. Nanoparticles are typically injected intravenously, however, Miragoli et al. delivered calcium phosphate nanoparticles with peptide payloads via inhalation to treat diabetic cardiomyopathy in rodent models. These nanoparticles rapidly homed to the heart tissue and improved cardiac function. Nanoparticles inhaled by healthy pigs also quickly reached the heart, suggesting this non-invasive route of administering cardiac-targeted drugs could have translational potential. [CREDIT: ELLA MARUSHCHENKO, ALEXANDER TOKAREV/ELLA MARU STUDIO]